DRSC/TRiP Functional Genomics Resources

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Protein Alignment eyg and ARX

DIOPT Version :10

Sequence 1:NP_524042.2 Gene:eyg / 39419 FlyBaseID:FBgn0000625 Length:670 Species:Drosophila melanogaster
Sequence 2:NP_620689.1 Gene:ARX / 170302 HGNCID:18060 Length:562 Species:Homo sapiens


Alignment Length:669 Identity:151/669 - (22%)
Similarity:197/669 - (29%) Gaps:312/669 - (46%)


- Green bases have known domain annotations that are detailed below.


  Fly    22 SAAHWKMEPH-PQRITSL-APHASSVAAASVAAAAAAAAAAAAAAAGAGSGAVAGGGGATSTSPT 84
            |:|.::.|.| |.::..| .|....:...:.||||||||||||||.     |.||..|.....|.
Human    71 SSAPFEAELHLPPKLRRLYGPGGGRLLQGAAAAAAAAAAAAAAAAT-----ATAGPRGEAPPPPP 130

  Fly    85 SVQIPPGFGGGGSTGGIPHGAGGPTGSTLNTLMSQHRLLEFSRFGGLRGYDIAQHMLTQQGAVSK 149
            ....|         |..|.|||....:..                                    
Human   131 PTARP---------GERPDGAGAAAAAAA------------------------------------ 150

  Fly   150 LLGSLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSINR 214
                                              ....||:..:  ||:       ||.||    
Human   151 ----------------------------------AAAAAWDTLK--ISQ-------APQVS---- 168

  Fly   215 ILRNRAAERVATEFARTAAYGLYPPPPHPYGSFTWHPAGNVPGGQGVPPPPPPSALWSVAAPTLA 279
                         .:|:.:|                      ...|.|..|||.||..:..|...
Human   169 -------------ISRSKSY----------------------RENGAPFVPPPPALDELGGPGGV 198

  Fly   280 NLPPSAASAVPVSTCGSLSSAHLMAGGAGGTPTNRAISPGSGSHDTLESA---DENRHIDSDYLD 341
            ..|.....               :|||.|..|   |...|:|:.|..|..   :|:...:.:.|:
Human   199 THPEERLG---------------VAGGPGSAP---AAGGGTGTEDDEEELLEDEEDEDEEEELLE 245

  Fly   342 DDDEP------------------------------------------------------------ 346
            ||:|.                                                            
Human   246 DDEEELLEDDARALLKEPRRCPVAATGAVAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDS 310

  Fly   347 ----------------KFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTSLSEARVQVW 395
                            |.||.||||:..||||||:.|.|:|||.|.|||.|:.|..|:|||||||
Human   311 VCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVW 375

  Fly   396 FSNRRAKWRRHQRMNLLKRQRSSPANPLHSQQSNDAPAS-----SPTPSNH--------SSASTS 447
            |.|||||||:.::..   .|...|..|.....|...|.|     ||.|.:|        ::|:.:
Human   376 FQNRRAKWRKREKAG---AQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAA 437

  Fly   448 APVAPVPPPQQPLPLCGDHSPQGPPPSVLLHPLHGPPGGHHHHHPLHLPTHPAALQLLSHYHQQQ 512
            |...|..||              ||.|..|     ||.|    .||.|.|...| .:..|     
Human   438 AAAFPSLPP--------------PPGSASL-----PPSG----APLGLSTFLGA-AVFRH----- 473

  Fly   513 QQQQQQQHQQQQQQHHQQQQQLSPSGCNPAANHLSMGGERSAFRSLVSSPSAAAFL--------G 569
                                   |:..:||...|.     |....|.|:.:|||.|        |
Human   474 -----------------------PAFISPAFGRLF-----STMAPLTSASTAAALLRQPTPAVEG 510

  Fly   570 LARQYAVAASLTVAEEQRS 588
            .....|:|...|.|.::|:
Human   511 AVASGALADPATAAADRRA 529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eygNP_524042.2 HTH_ARSR 120..217 CDD:481197 8/96 (8%)
Homeodomain 349..405 CDD:459649 38/55 (69%)
ARXNP_620689.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..81 3/9 (33%)
GCG-encoded polyalanine repeat 102..111 8/8 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..255 44/281 (16%)
Homeodomain 329..385 CDD:459649 38/55 (69%)
OAR 526..544 CDD:461067 1/4 (25%)
OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138 530..543 151/669 (23%)
Blue background indicates that the domain is not in the aligned region.

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