DRSC/TRiP Functional Genomics Resources

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Protein Alignment eyg and Pitx1

DIOPT Version :10

Sequence 1:NP_524042.2 Gene:eyg / 39419 FlyBaseID:FBgn0000625 Length:670 Species:Drosophila melanogaster
Sequence 2:NP_446076.1 Gene:Pitx1 / 113983 RGDID:69253 Length:315 Species:Rattus norvegicus


Alignment Length:379 Identity:104/379 - (27%)
Similarity:144/379 - (37%) Gaps:113/379 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   262 PPPPPPSALWSVAAPTLANLPPSAASAVPVSTCGSLSS-AHL---MAGGAGGTPTN-RAISPGSG 321
            ||||||..:    .|:. :|..:|....|:....|.|| |.|   ..||....|.: .|.|.|.|
  Rat    19 PPPPPPHDM----GPSF-HLARTADPREPLENSASESSDADLPDKERGGEAKVPEDGGAGSAGCG 78

  Fly   322 SHDTLESADENRHIDSDYLDDDDEPKFRRNRTTFSPEQLEELEKEFDKSHYPCVSTRERLSSRTS 386
            |.:                |...:.|.||.||.|:.:||:|||..|.::.||.:|.||.::..|:
  Rat    79 SAE----------------DPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTN 127

  Fly   387 LSEARVQVWFSNRRAKWR---RHQRMNLLK----RQRSSPANPLHSQQSNDAPASSPTPSNHSSA 444
            |:|.||:|||.|||||||   |:|:::|.|    .|.|....|.     .|..|::....|:.:|
  Rat   128 LTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGLVQPY-----EDVYAAAGYSYNNWAA 187

  Fly   445 STSAPVAPVPPPQQPLPLCGDHSPQ------GPPPSV--LLHPLHGPPGGHHHHHPLHLPTHPAA 501
            .:   :||.|...:........||.      ..|.|:  :..|....||.        :|..|  
  Rat   188 KS---LAPAPLSTKSFTFFNSMSPLSSQSMFSAPSSISSMTMPSSMGPGS--------VPGMP-- 239

  Fly   502 LQLLSHYHQQQQQQQQQQHQQQQQQHHQQQQQLSPSGCNPAANHLSMGGERSAFRSLVSSPSAAA 566
                                              .||.| ..|:|:.....||.     ||.|..
  Rat   240 ----------------------------------NSGLN-NINNLTGSSLNSAM-----SPGACP 264

  Fly   567 FLGLARQYAV--------AASLTVAEEQRSRLHYSAGGLGSGGEGTGPNTNTTQ 612
            :...|..|:|        .|||.:..:|.|...|  |||    :|.....|..|
  Rat   265 YGTPASPYSVYRDTCNSSLASLRLKSKQHSSFGY--GGL----QGPASGLNACQ 312

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eygNP_524042.2 HTH_ARSR 120..217 CDD:481197
Homeodomain 349..405 CDD:459649 31/58 (53%)
Pitx1NP_446076.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..103 32/104 (31%)
Homeodomain 90..146 CDD:459649 30/55 (55%)
Interaction with PIT-1. /evidence=ECO:0000250 149..280 36/188 (19%)
OAR 277..294 CDD:461067 4/16 (25%)
OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138 281..294 4/12 (33%)
Nuclear localization signal. /evidence=ECO:0000255 287..291 0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

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