DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Hoxd9

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001166940.1	Gene:	Hoxd9 / 688999	RGDID:	1582908	Length:	343	Species:	Rattus norvegicus

Alignment Length:	302	Identity:	76/302 - (25%)
Similarity:	104/302 - (34%)	Gaps:	113/302 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 AAAEFAR----------AASYGYAIHPTHP---------HPYTSFPTWPAHHP-----LWGAVPL 277
            ||||||.          :||:. |:....|         |||.|.|...|..|     .| ..||
  Rat    48 AAAEFASCSFAPKSSVFSASWS-AVAAQPPAAATMSGLYHPYVSPPPLAAAEPGRYVRSW-MEPL 110

  Fly   278 ATPPGGGPAGAGGALQPGGSGSS-----------------YG------------SDGNMSSNPNS 313
            ...|||  ||.||....||.|.|                 ||            :....||..:|
  Rat   111 PGFPGG--AGGGGGSGGGGGGGSGGPGPVPSPGGPANGRHYGIKPETGAAPAPSAASTSSSTSSS 173

  Fly   314 SNSNTTHSNGHNTNSGSG-----CGD-----------SSAGSGRLSLPAL-----------SPDS 351
            |:|..|..:....:.|||     |..           ::||:|    |.:           |..|
  Rat   174 SSSKRTECSAARESQGSGGPEFPCNSFLRDKAAAAAAAAAGNG----PGVGIGTGPGTGGSSEPS 234

  Fly   352 GSRDSRSPDADANRMIDIEGEDSESQDSDQPK-----------------FRRNRTTFSPEQLDEL 399
            ...|..||....        ::.|.|....|:                 .|:.|..::..|..||
  Rat   235 ACSDHPSPGCPL--------KEEEKQPPQPPQQQLDPNNPAANWIHARSTRKKRCPYTKYQTLEL 291

  Fly   400 EKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRR 441
            ||||..:.|...:.|.::|....|:|.:|::||.|||.|.::
  Rat   292 EKEFLFNMYLTRDRRYEVARILNLTERQVKIWFQNRRMKMKK 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	20/51 (39%)
Hoxd9	NP_001166940.1	Hox9_act	1..>155	CDD:282473	33/110 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..196		22/84 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..267		8/54 (15%)
		HOX	276..328	CDD:197696	18/51 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910