DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Hoxa6

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001178016.1	Gene:	Hoxa6 / 685732	RGDID:	1590236	Length:	233	Species:	Rattus norvegicus

Alignment Length:	235	Identity:	61/235 - (25%)
Similarity:	97/235 - (41%)	Gaps:	60/235 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 YAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQPGGSGSSYGSDGNMSSNPNS 313
            |.::||.|   .|.|:  ......|.:||.      |||. .||:|  ..:|||:    ||.|:.
  Rat     4 YFVNPTFP---GSLPS--GQDSFLGQLPLY------PAGY-DALRP--FPASYGA----SSLPDK 50

  Fly   314 S--------NSNTTHS-NGHNTNSGSGC--------GDSSAGSGRLSLPA----LSPDSGSRDSR 357
            :        .||:..: |..:...|:.|        |.|.:|:.:...|.    .||:    ...
  Rat    51 TYTSPCFYQQSNSVLACNRASYEYGASCFYSDKDLSGASPSGNSKQRGPGDYLHFSPE----QQY 111

  Fly   358 SPDADA--NRMIDIEGEDSESQDSDQPKF---------------RRNRTTFSPEQLDELEKEFDK 405
            .||:.:  .:.:..||.|.:......|..               ||.|.|::..|..||||||..
  Rat   112 KPDSSSVQGKALHEEGTDRKYTSPVYPWMQRMNSCAGAVYGSHGRRGRQTYTRYQTLELEKEFHF 176

  Fly   406 SHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRV 445
            :.|.....|.::|....|:|.::::||.|||.||::..::
  Rat   177 NRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKENKL 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	20/51 (39%)
Hoxa6	NP_001178016.1	Homeobox	159..212	CDD:395001	21/52 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910