DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Nkx3-2

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_008768461.2	Gene:	Nkx3-2 / 682329	RGDID:	1584617	Length:	328	Species:	Rattus norvegicus

Alignment Length:	307	Identity:	67/307 - (21%)
Similarity:	105/307 - (34%)	Gaps:	116/307 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 GGPAGAGGALQPGG---------------------SGSSYGSDGNMSSNPNSSNSNTTHSNGHNT 326
            ||.|...|...|||                     :|:..|::.::.::|    :.|..:.||:.
  Rat    25 GGLAAPEGRPAPGGTEVAVAAAPAVCCWRLFGETEAGALGGAEDSLLASP----ARTRTAVGHSA 85

  Fly   327 NSGSG----------------CGD----SSAGSGRLSL-------------PALSPD-------S 351
            .|..|                |.|    |..|..|::|             ..:..|       |
  Rat    86 ESPGGWDSDSALSEENEGRRRCADVPGASGTGHARVTLGLEQHAAKDLEEEARIRSDSEMSASVS 150

  Fly   352 GSRDSRSPDADAN----RMIDIEG--------------EDSESQDSDQPKFRRNRTTFSPEQLDE 398
            |....|..|...:    |:..:.|              |:.|...:.:|:.:|:|..||..|:.|
  Rat   151 GDHSPRGEDGSVSPGGARVPGLCGTAGGGASSGQAGGVEEEEEPAAPKPRKKRSRAAFSHAQVFE 215

  Fly   399 LEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTP- 462
            ||:.|:...|.....|..|||...|:|.:|::||.|||.|.:|       :|..:...:|:|..
  Rat   216 LERRFNHQRYLSGPERADLAASLKLTETQVKIWFQNRRYKTKR-------RQMAADLLASAPAAK 273

  Fly   463 ---------------LVNPVVSPVSPIPVPVPVAVPESGQQKQPYPY 494
                           |...|:.|.|.:|:          |....|||
  Rat   274 KVAVKVLVRDDQRQYLPGEVLRPPSLLPL----------QPSYYYPY 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	22/51 (43%)
Nkx3-2	XP_008768461.2	Homeobox	204..258	CDD:395001	22/53 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910