DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and alx1

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001038539.1	Gene:	alx1 / 565176	ZFINID:	ZDB-GENE-050419-191	Length:	320	Species:	Danio rerio

Alignment Length:	278	Identity:	87/278 - (31%)
Similarity:	114/278 - (41%)	Gaps:	42/278 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 PGGSGSSYGSDGNMSSNPN---------------SSNSNTTHSN------GHNTNSGSGCGDSSA 337
            |...||.|..|..|.:..|               ...||..||:      ..|.:|.:.|...|.
Zfish    13 PAIKGSDYYMDQVMDTLDNVQYYNKASPKCVQAFPMQSNDQHSSMDRSSPCDNQSSVTYCAPKSE 77

  Fly   338 GSGRLSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKE 402
            .|   ||.|:......|.|.:........:|..||..:|..|...| ||:||||:..||:||||.
Zfish    78 ES---SLHAMENCCSLRVSPATSGPDKTDLDELGEKCDSNVSSSKK-RRHRTTFTSAQLEELEKV 138

  Fly   403 FDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDS-----------PST 456
            |.|:|||.|..||:||.||.|:||||||||.|||||||:.:|...|:|..|           |.|
Zfish   139 FQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISMLPRT 203

  Fly   457 SSSPTPLVNPVVSPVSPIPVPVPVAVPESGQQ--KQPYPYS----TSNMCNTSSSSSNSQPCNTI 515
            .|......|....|.:...|.....:|.....  ..|||:|    ........:...|....|.:
Zfish   204 DSYSQISNNLWTGPSAGSSVVSSCMIPRGSPPCVTSPYPHSPRAAEHGYVGFPNHQQNQFGVNHV 268

  Fly   516 NPGSKMSSKTSSVSSNQH 533
            :..:..:....:.|:|.|
Zfish   269 SLNNFFADSLLASSANSH 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	36/51 (71%)
alx1	NP_001038539.1	Homeobox	123..176	CDD:278475	36/52 (69%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:Q63087	180..320		20/107 (19%)
		OAR	296..313	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	300..313
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910