Protein Alignment toe and alx1

DIOPT Version :10

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_001038539.1
• Gene: alx1 / 565176
• ZFINID: ZDB-GENE-050419-191
• Length: 320
• Species: Danio rerio
• Alignment Length: 278
• Identity: 87/278 - (31%)
• Similarity: 114/278 - (41%)
• Gaps: 42/278 - (15%)

  Fly   294 PGGSGSSYGSDGNMSSNPN---------------SSNSNTTHSN------GHNTNSGSGCGDSSA 337
            |...||.|..|..|.:..|               ...||..||:      ..|.:|.:.|...|.
Zfish    13 PAIKGSDYYMDQVMDTLDNVQYYNKASPKCVQAFPMQSNDQHSSMDRSSPCDNQSSVTYCAPKSE 77

  Fly   338 GSGRLSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKE 402
            .|   ||.|:......|.|.:........:|..||..:|..|...| ||:||||:..||:||||.
Zfish    78 ES---SLHAMENCCSLRVSPATSGPDKTDLDELGEKCDSNVSSSKK-RRHRTTFTSAQLEELEKV 138

  Fly   403 FDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDS-----------PST 456
            |.|:|||.|..||:||.||.|:||||||||.|||||||:.:|...|:|..|           |.|
Zfish   139 FQKTHYPDVYVREQLAMRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISMLPRT 203

  Fly   457 SSSPTPLVNPVVSPVSPIPVPVPVAVPESGQQ--KQPYPYS----TSNMCNTSSSSSNSQPCNTI 515
            .|......|....|.:...|.....:|.....  ..|||:|    ........:...|....|.:
Zfish   204 DSYSQISNNLWTGPSAGSSVVSSCMIPRGSPPCVTSPYPHSPRAAEHGYVGFPNHQQNQFGVNHV 268

  Fly   516 NPGSKMSSKTSSVSSNQH 533
            :..:..:....:.|:|.|
Zfish   269 SLNNFFADSLLASSANSH 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH_ARSR	134..230	CDD:481197
		Homeodomain	385..441	CDD:459649	39/55 (71%)
alx1	NP_001038539.1	Homeodomain	121..177	CDD:459649	39/55 (71%)
		Transactivation domain. /evidence=ECO:0000250|UniProtKB:Q63087	180..320		20/107 (19%)
		OAR	296..314	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	300..313