Protein Alignment toe and PROP1

DIOPT Version :9

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_006252.4
• Gene: PROP1 / 5626
• HGNCID: 9455
• Length: 226
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 85/333 - (25%)
• Similarity: 107/333 - (32%)
• Gaps: 127/333 - (38%)

  Fly   233 AAERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQPGGS 297
            |..|..||..:....|..:.|.. ||.|..||        ..|..:.||.....||||
Human     3 AERRRQAEKPKKGRVGSNLLPER-HPATGTPT--------TTVDSSAPPCRRLPGAGG------- 51

  Fly   298 GSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDSRSPDAD 362
                   |....:|........||.
Human    52 -------GRSRFSPQGGQRGRPHSR---------------------------------------- 69

  Fly   363 ANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEAR 427
                                  ||:||||||.||::||..|.::.||.:..||.||..|.|||||
Human    70 ----------------------RRHRTTFSPVQLEQLESAFGRNQYPDIWARESLARDTGLSEAR 112

  Fly   428 VQVWFSNRRAKWRRHQRVNLIK--QRDSPSTSSSPTPLVNPVVSPVSPIPVPVPVAVPESGQQKQ 490
            :||||.|||||.|:.:| :|::  ...||:..||..|  .....|.|....|.||..       .
Human   113 IQVWFQNRRAKQRKQER-SLLQPLAHLSPAAFSSFLP--ESTACPYSYAAPPPPVTC-------F 167

  Fly   491 PYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSSKTSSVSSNQHMEE---------PAAAVATASP 546
            |:||         |.:..|||            .|....:..|..|         ||..:....|
Human   168 PHPY---------SHALPSQP------------STGGAFALSHQSEDWYPTLHPAPAGHLPCPPP 211

  Fly   547 TASAPLSM 554
            ....|||:
Human   212 PPMLPLSL 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
		Homeobox	388..440	CDD:278475	32/51 (63%)
PROP1	NP_006252.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		25/156 (16%)
		Homeobox	72..126	CDD:395001	32/53 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..226		6/24 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910