Protein Alignment toe and PROP1

DIOPT Version :10

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_006252.4
• Gene: PROP1 / 5626
• HGNCID: 9455
• Length: 226
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 85/332 - (25%)
• Similarity: 108/332 - (32%)
• Gaps: 125/332 - (37%)

  Fly   233 AAERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQPGGS 297
            |..|..||..:....|..:.|.. ||.|..||        ..|..:.||.....||||
Human     3 AERRRQAEKPKKGRVGSNLLPER-HPATGTPT--------TTVDSSAPPCRRLPGAGG------- 51

  Fly   298 GSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDSRSPDAD 362
                   |....:|........||.
Human    52 -------GRSRFSPQGGQRGRPHSR---------------------------------------- 69

  Fly   363 ANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEAR 427
                                  ||:||||||.||::||..|.::.||.:..||.||..|.|||||
Human    70 ----------------------RRHRTTFSPVQLEQLESAFGRNQYPDIWARESLARDTGLSEAR 112

  Fly   428 VQVWFSNRRAKWRRHQRVNLIK--QRDSPSTSSSPTPLVNPVVSPVSPIPVPVPVAVPESGQQKQ 490
            :||||.|||||.|:.:| :|::  ...||:..||..|  .....|.|....|.||..       .
Human   113 IQVWFQNRRAKQRKQER-SLLQPLAHLSPAAFSSFLP--ESTACPYSYAAPPPPVTC-------F 167

  Fly   491 PYPY--------STSNMCNTSSSSSNSQPCNTINPGSKMSSKTSSVSSNQHMEEPAAAVATASPT 547
            |:||        ||......|..|.:..|  |::|.                  ||..:....|.
Human   168 PHPYSHALPSQPSTGGAFALSHQSEDWYP--TLHPA------------------PAGHLPCPPPP 212

  Fly   548 ASAPLSM 554
            ...|||:
Human   213 PMLPLSL 219

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH_ARSR	134..230	CDD:481197
		Homeodomain	385..441	CDD:459649	34/55 (62%)
PROP1	NP_006252.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..75		25/156 (16%)
		Homeodomain	70..126	CDD:459649	34/55 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	196..226		9/44 (20%)