DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and BARX1

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_067545.3	Gene:	BARX1 / 56033	HGNCID:	955	Length:	254	Species:	Homo sapiens

Alignment Length:	278	Identity:	73/278 - (26%)
Similarity:	97/278 - (34%)	Gaps:	75/278 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 RAAERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQPGG 296
            |..|..||.|  ....|.|.|  .||.|.||.....         |..||  ||.||..|.....
Human     3 RPGEPGAARF--GPPEGCADH--RPHRYRSFMIEEI---------LTEPP--GPKGAAPAAAAAA 52

  Fly   297 SGS--SYGSDGNMSSNPNSSNSNTTHSNGHNTNSGS---------GC-GDSSA----------GS 339
            :|.  .:|....:::.|..|     |.........:         || |.|||          .:
Human    53 AGELLKFGVQALLAARPFHS-----HLAVLKAEQAAVFKFPLAPLGCSGLSSALLAAGPGLPGAA 112

  Fly   340 GRLSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFD 404
            |...||......|..::..|           ||..    :...|.||:||.|:..||..|||.|:
Human   113 GAPHLPLELQLRGKLEAAGP-----------GEPG----TKAKKGRRSRTVFTELQLMGLEKRFE 162

  Fly   405 KSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTPLVNPVVS 469
            |..|.....|..||....||:.:|:.|:.|||.||::     ::.|...             :.|
Human   163 KQKYLSTPDRIDLAESLGLSQLQVKTWYQNRRMKWKK-----IVLQGGG-------------LES 209

  Fly   470 PVSPIPVPVPVAVPESGQ 487
            |..|...|...::|.|.|
Human   210 PTKPKGRPKKNSIPTSEQ 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	22/51 (43%)
BARX1	NP_067545.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		6/18 (33%)
		Homeobox	145..199	CDD:395001	23/53 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..254		7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910