DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and lhx9

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001032320.2	Gene:	lhx9 / 550405	ZFINID:	ZDB-GENE-050417-210	Length:	396	Species:	Danio rerio

Alignment Length:	215	Identity:	56/215 - (26%)
Similarity:	87/215 - (40%)	Gaps:	68/215 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 SGCGDSSAGSGR-LSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQ------PKFRRN 387
            :|.|....|..| ...||:..|.||..|...:.||:.:           |.||      .|.:|.
Zfish   217 NGTGTVQKGRPRKRKSPAMGIDIGSYSSGCNENDADHL-----------DRDQQPYPPSQKTKRM 270

  Fly   388 RTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRD 452
            ||:|...||..::..|..:|.|.....::||.:|.|::..:||||.|.|||:||    |:::|.:
Zfish   271 RTSFKHHQLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRR----NVLRQEN 331

  Fly   453 S----------------------PSTSSSPTPLVNPVVSPVSPIPVPVPVAVPESGQQKQPYPYS 495
            .                      |||:::.|.|.||.::.|:.:
Zfish   332 GGVDKADGTSLPPPSSDSGALTPPSTATTLTDLTNPSITVVTSV--------------------- 375

  Fly   496 TSNMCNTSSSSSNSQPCNTI 515
            ||::   .|..|.|.|..|:
Zfish   376 TSSL---DSHESGSPPQTTL 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	20/51 (39%)
lhx9	NP_001032320.2	LIM1_Lhx2	61..124	CDD:188853
		LIM2_Lhx2_Lhx9	129..187	CDD:188763
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..272		7/34 (21%)
		Homeobox	271..323	CDD:278475	20/51 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..365		5/36 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..396		6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910