DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and dmbx1b

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001017625.1	Gene:	dmbx1b / 550288	ZFINID:	ZDB-GENE-050417-97	Length:	369	Species:	Danio rerio

Alignment Length:	297	Identity:	84/297 - (28%)
Similarity:	119/297 - (40%)	Gaps:	79/297 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 ANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEAR 427
            |.|:.||..|  ....|...|.||:||.|:.:||:.|||.|.|:|||.|..||:||..|.|.|||
Zfish    47 AERLADIILE--ARYGSQHRKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEAR 109

  Fly   428 VQVWFSNRRAKWRRHQR------VNLIKQRDSPSTSSSPTPLVNPVVSPVSPIPV---------- 476
            |||||.|||||:|:.||      :..:|:..:............||.:...|.|:
Zfish   110 VQVWFKNRRAKFRKKQRSLQKEQLQRLKEAGTEGAQDEGKEEAPPVEAQAPPSPLDGRGLTSAPS 174

  Fly   477 -----PVPVAVP-----ESGQQ----KQPYPYSTSNMCN-------TSSSSSNSQPCNTINPGSK 520
                 .|.|..|     |||.:    ::..|.|..:...       |..||.:.:|
Zfish   175 CELNEEVNVTSPEQSGAESGAEDTTDREDEPLSIKDEIKEAGPPLMTDDSSPSYKP--------- 230

  Fly   521 MSSKTSSVSSNQHMEEPAAAVATASPTASAPLS-----------MGGENSAFRALPMTLPMPMTL 574
            :|.|:.....:..:...:.|||.::..||:|||           |...|:........:..|.:|
Zfish   231 LSPKSDDPLVSPALPSSSGAVAQSNSYASSPLSLFRLQEQFRQHMAATNNLMHYPAFDVTAPSSL 295

  Fly   575 PTASAAAFALSFARQYIAKYMGTPLNLGH--GSSPIQ 609
            |                  |:|..:|:..  ||.|.|
Zfish   296 P------------------YLGVNVNMASPLGSLPCQ 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	33/51 (65%)
dmbx1b	NP_001017625.1	Homeobox	69..122	CDD:278475	33/52 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..253		23/137 (17%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	346..359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910