DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and pitx2

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001017227.1	Gene:	pitx2 / 549981	XenbaseID:	XB-GENE-482492	Length:	345	Species:	Xenopus tropicalis

Alignment Length:	259	Identity:	77/259 - (29%)
Similarity:	120/259 - (46%)	Gaps:	68/259 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 GSGCGDSSAGSGRLSLPALSPDSGSRDSRSPD-ADANRMIDIEGEDSESQD-SDQPKFRRNRTTF 391
            |...|:..|   ||.:..:|      |:.||: ||.::....:.|||.:.| |.:.:.||.||.|
Frog    65 GQRSGECKA---RLEVHTIS------DTSSPEAADKDKSHQSKNEDSSTDDPSKKKRQRRQRTHF 120

  Fly   392 SPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWR---RHQRVNLIKQRDS 453
            :.:||.|||..|.::.||.::|||::|..|.|:||||:|||.|||||||   |:|:..|.|....
Frog   121 TSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFG 185

  Fly   454 P-----------------------------STSSSPTPLVNPV-VSPVSPIPVPVPVAVPESGQQ 488
            |                             |.|:...|..|.: |:|:|...:
Frog   186 PQFNGLMQPYDDMYPSYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSM------------ 238

  Fly   489 KQPYPYSTSNMCNTSSSSSNSQPCNTIN-PGSKMSSKTSSVSSNQHMEEPAAAVATASPTASAP 551
                 :|:.|..::.|.||...|..... |||.:    :|:::..::..|  ::.||.||::.|
Frog   239 -----FSSPNSISSMSMSSGMVPSAVTGVPGSGL----NSLNNLNNLSNP--SLNTAVPTSACP 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	29/51 (57%)
pitx2	NP_001017227.1	XRCC4	<84..144	CDD:284132	23/59 (39%)
		Homeobox	117..169	CDD:278475	29/51 (57%)
		OAR	303..320	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910