DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and pou3f1

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001016504.1	Gene:	pou3f1 / 549258	XenbaseID:	XB-GENE-853354	Length:	375	Species:	Xenopus tropicalis

Alignment Length:	350	Identity:	72/350 - (20%)
Similarity:	99/350 - (28%)	Gaps:	151/350 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 GYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQPGGSGSSYGSDGNMSSNPN 312
            |.|.:..||...|       ||. |      .|......|:|..|   |:.:.:|..|..||..:
Frog    47 GLATNAGHPMSLT-------HHQ-W------LPNPASDWGSGSHL---GAQAEHGKSGVQSSRED 94

  Fly   313 SSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRD----SRSPDADANRMI------ 367
            .| |:..|...|..:..:....:.|.||...||.:||.|.|..    |:|...:.|.|:
Frog    95 LS-SSFHHHRSHLVHQQTPSSHAWAQSGGHHLPPMSPGSNSHQPLIYSQSSYTNLNGMLGPQASS 158

  Fly   368 -------------------------------DIEGEDSESQD-----SDQPKFRR---------- 386
                                           |...||:.|.|     :.|.|.||
Frog   159 LHHSMRDPLHDDPGVLDTHVESPPQHLSHHQDHSDEDAPSSDDLEQFAKQFKQRRIKLGFTQADV 223

  Fly   387 --------------------------------------------NRTTFSPEQLDE--------- 398
                                                        :.||.||..||:
Frog   224 GLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEETDSTTGSPTNLDKIAAQGRKRK 288

  Fly   399 ------------LEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQR 451
                        ||..|.|...|..:....||....|.:..|:|||.|||.|          ::|
Frog   289 KRTSIEVGVKGALENHFLKCPKPSAHEITSLADSLQLEKEVVRVWFCNRRQK----------EKR 343

  Fly   452 DSPSTSSSPTPLVNPVVSPVSPIPV 476
            .:|  :..|.|.:..|.|.....|:
Frog   344 MTP--AGVPHPPMEDVYSQAETPPL 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	22/72 (31%)
pou3f1	NP_001016504.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..139		26/100 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..200		5/48 (10%)
		POU	194..268	CDD:197673	8/73 (11%)
		Homeobox	289..343	CDD:365835	16/63 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910