DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toe and otx2

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_012823826.1	Gene:	otx2 / 548931	XenbaseID:	XB-GENE-485220	Length:	306	Species:	Xenopus tropicalis

Alignment Length:	223	Identity:	70/223 - (31%)
Similarity:	108/223 - (48%)	Gaps:	50/223 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   383 KFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQ---- 443
            |.||.||||:..|||.||..|.|:.||.:..||::|.:..|.|:||||||.|||||.|:.|
Frog    54 KQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQ 118

  Fly   444 -----RVNLIKQRDSPS--------TS---SSPTPLVNPVV----------SPVSPIPVPVPVAV 482
                 :|...|::.||:        ||   |.|.....||:          ||.|..|:..|::.
Frog   119 NGGQNKVRPSKKKPSPAREVSSESGTSGQFSPPCSTSVPVISSSTAPVSIWSPASISPLSDPLST 183

  Fly   483 PESGQQKQ-PYPYSTSNMCNTSSSSSNS----QPCNT-INP--------GSKMSSK-TSSVSSNQ 532
            ..|..|:. |..|:.::..:...:.|.|    ..|.: :.|        |:.:|.. |::|:|
Frog   184 SSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLSGAGATLSPMGTNAVTS-- 246

  Fly   533 HMEEPAAAVATASPTASAPLSMGGENSA 560
            |:.:..||:::.:..||   |:|..::|
Frog   247 HLNQSPAALSSQAYGAS---SLGFNSTA 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	29/51 (57%)
otx2	XP_012823826.1	Homeobox	59..111	CDD:365835	29/51 (57%)
otx2	XP_012823826.1	TF_Otx	170..251	CDD:367546	19/82 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910