DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Pitx2

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001035970.1	Gene:	Pitx2 / 54284	RGDID:	3331	Length:	324	Species:	Rattus norvegicus

Alignment Length:	243	Identity:	74/243 - (30%)
Similarity:	112/243 - (46%)	Gaps:	48/243 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 AGSGRLSLPALSPDSGSRDSRSPD-ADANRMIDIEGEDSESQD-SDQPKFRRNRTTFSPEQLDEL 399
            |...||.:..:|      |:.||: |:.::....:.||..::| |.:.:.||.||.|:.:||.||
  Rat    49 ASKHRLEVHTIS------DTSSPEVAEKDKGQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQEL 107

  Fly   400 EKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWR---RHQRVNLIKQRDSPSTSSSPT 461
            |..|.::.||.::|||::|..|.|:||||:|||.|||||||   |:|:..|.|....|.
  Rat   108 EATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQ------ 166

  Fly   462 PLVNPVVSPVSPIPVP-------VPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTIN--- 516
              .|.::.|...: .|       ....:..:....:.:|:..|...|..||.|...|.|:|:
  Rat   167 --FNGLMQPYDDM-YPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMS 228

  Fly   517 -------------PGSKMSS-----KTSSVSSNQHMEEPAAAVATASP 546
                         |||.::|     ..||.|.|..:..||...|..:|
  Rat   229 MSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTP 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	29/51 (57%)
Pitx2	NP_001035970.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..111		19/59 (32%)
		Homeobox	96..149	CDD:395001	30/52 (58%)
		OAR	282..299	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	286..299
		Nuclear localization signal. /evidence=ECO:0000255	292..296
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910