Protein Alignment toe and PRRX2

DIOPT Version :10

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_057391.1
• Gene: PRRX2 / 51450
• HGNCID: 21338
• Length: 253
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 80/269 - (29%)
• Similarity: 115/269 - (42%)
• Gaps: 47/269 - (17%)

  Fly   282 GGGPAGAGGALQPGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSL-P 345
            |.||.....||.||                :.:.:....|..|..:.     :..|.:|||:. |
Human    16 GPGPPPPPPALGPG----------------DCAQARKNFSVSHLLDL-----EEVAAAGRLAARP 59

  Fly   346 ALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQP------------KFRRNRTTFSPEQLDE 398
            ....::....:|.|...::      |.::..||.:.|            |.|||||||:..||..
Human    60 GARAEAREGAAREPSGGSS------GSEAAPQDGECPSPGRGSAAKRKKKQRRNRTTFNSSQLQA 118

  Fly   399 LEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTPL 463
            ||:.|:::|||....||:||.|..||||||||||.|||||:||::|..|..:..|...|.|....
Human   119 LERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAMLASRSASLLKSYSQEAA 183

  Fly   464 VNPVVSPVSPIPVPVPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSSKTSSV 528
            :.   .||:|.|..:.   |:........||||....:..||...:...|..|..:.:..|....
Human   184 IE---QPVAPRPTALS---PDYLSWTASSPYSTVPPYSPGSSGPATPGVNMANSIASLRLKAKEF 242

  Fly   529 SSNQHMEEP 537
            |.: |.:.|
Human   243 SLH-HSQVP 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH_ARSR	134..230	CDD:481197
		Homeodomain	385..441	CDD:459649	35/55 (64%)
PRRX2	NP_057391.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		7/32 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	55..113		16/63 (25%)
		Homeodomain	109..161	CDD:459649	31/51 (61%)
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	230..243		2/12 (17%)