DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toe and PAX9

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001359005.1	Gene:	PAX9 / 5083	HGNCID:	8623	Length:	341	Species:	Homo sapiens

Alignment Length:	258	Identity:	89/258 - (34%)
Similarity:	123/258 - (47%)	Gaps:	42/258 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLLGTLR 168
            |||:|..|....            ||:  :.|::||::.|:|..|:::.:....|.|||:|....
Human    11 LGGVFVNGRPLP------------NAI--RLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYN 61

  Fly   169 P-----PGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINRI 228
            .     ||.||||||:|.|||||..|..||:.:|.|||||||:||:.:|||.....||||||:||
Human    62 ETGSILPGAIGGSKPRVTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRI 126

  Fly   229 LRNRAAERAAAEFARAASY-GYAIHPTHPH---PYTSFPTWPAHHPLWGAVPLATPPGGGPAGAG 289
            |||:     ....|:...| .|..|...|.   ||....::|:  |:..|......|.|.||..|
Human   127 LRNK-----IGNLAQQGHYDSYKQHQPTPQPALPYNHIYSYPS--PITAAAAKVPTPPGVPAIPG 184

  Fly   290 GALQPGGSGSSYG-SD--GNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSP 349
            ....|....||:. :|  |..|.....|:|:..||..         .:..:..||.:.||.:|
Human   185 SVAMPRTWPSSHSVTDILGIRSITDQVSDSSPYHSPK---------VEEWSSLGRNNFPAAAP 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	49/100 (49%)
toe	NP_524041.2	Homeobox	388..440	CDD:278475
PAX9	NP_001359005.1	PAX	6..131	CDD:238076	59/138 (43%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	7..63		18/65 (28%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	82..130		29/47 (62%)
		Interaction with KDM5B. /evidence=ECO:0000269\|PubMed:12657635	168..189		6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910