Protein Alignment toe and PAX7

DIOPT Version :9

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_002575.1
• Gene: PAX7 / 5081
• HGNCID: 8621
• Length: 520
• Species: Homo sapiens
• Alignment Length: 705
• Identity: 177/705 - (25%)
• Similarity: 254/705 - (36%)
• Gaps: 292/705 - (41%)

  Fly    19 SLPGAAPAIPATATAGSQSPGAIMPMAAVPLPSHLQLLGSSAGGVGQPAAITPVSPTAATTVLAQ 83
            :|||..|.:...|      ||...|....|
Human     3 ALPGTVPRMMRPA------PGQNYPRTGFP----------------------------------- 26

  Fly    84 PHSLSPSTPILTQGAPPAAALGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYD 148
               |..|||:   |......|||:|..|....            |.:  :|:::|::..|:|...
Human    27 ---LEVSTPL---GQGRVNQLGGVFINGRPLP------------NHI--RHKIVEMAHHGIRPCV 71

  Fly   149 LAQHMLSQQGAVSKLL------GTLRPPGLIGGSKPK-VATPTVVSKIEQYKRENPTIFAWEIRE 206
            :::.:....|.|||:|      |::| ||.||||||: ||||.|..|||:||||||.:|:||||:
Human    72 ISRQLRVSHGCVSKILCRYQETGSIR-PGAIGGSKPRQVATPDVEKKIEEYKRENPGMFSWEIRD 135

  Fly   207 RLITEGVCTNATAPS--VSSINRILRNRAAERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHH 269
            ||:.:|.|..:|.||  ||||:|:||.:..::...:.|....
Human   136 RLLKDGHCDRSTVPSGLVSSISRVLRIKFGKKEEEDEADKKE----------------------- 177

  Fly   270 PLWGAVPLATPPGGGPAGAGGALQPGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGD 334
                                                                            |
Human   178 ----------------------------------------------------------------D 178

  Fly   335 SSAGSGRLSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQP---KFRRNRTTFSPEQL 396
            ......:.|:..:..|.|:|            :| ||.|.|| :.|.|   |.||:||||:.|||
Human   179 DGEKKAKHSIDGILGDKGNR------------LD-EGSDVES-EPDLPLKRKQRRSRTTFTAEQL 229

  Fly   397 DELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIK------------ 449
            :||||.|:::|||.:.|||:||.||.|:|||||||||||||:||:....|.:.
Human   230 EELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLAAFNHLLPGGFPP 294

  Fly   450 ---------------------QRDSPSTSSSPTPL------------------------------ 463
                                 .:|..||...|.||
Human   295 TGMPTLPPYQLPDSTYPTTTISQDGGSTVHRPQPLPPSTMHQGGLAAAAAAADTSSAYGARHSFS 359

  Fly   464 ---------------VNPVVSPVSPIPVPV---PVAVPESGQQKQPYP---YSTSNM-----CNT 502
                           :|||.:.:||..:.:   |.|||       |.|   :|.|.:     ..|
Human   360 SYSDSFMNPAAPSNHMNPVSNGLSPQVMSILGNPSAVP-------PQPQADFSISPLHGGLDSAT 417

  Fly   503 SSSSSNSQPCNTINPGSKMSSKTSSVSSNQHMEEPAAAVA--TASPTASAPLSMGGENSAFRALP 565
            |.|:|.||..::|.||       .|:.::|....|..:..  :..|.|.......|::...  :|
Human   418 SISASCSQRADSIKPG-------DSLPTSQAYCPPTYSTTGYSVDPVAGYQYGQYGQSECL--VP 473

  Fly   566 MTLPMPMTLPTASAAAFALSFARQYIAKYMGTPLNLGHGSSPIQAQSGRDHQSEE 620
            ...|:|:..||..|:..   |...|  |.:.     |.|.|..|.:..:..|.|:
Human   474 WASPVPIPSPTPRASCL---FMESY--KVVS-----GWGMSISQMEKLKSSQMEQ 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	50/104 (48%)
		Homeobox	388..440	CDD:278475	36/51 (71%)
PAX7	NP_002575.1	paired box domain	34..164		59/144 (41%)
		PAX	34..163	CDD:238076	59/143 (41%)
		octapeptide	86..93		1/6 (17%)
		paired homeodomain	217..275		40/57 (70%)
		Homeobox	220..273	CDD:278475	36/52 (69%)
		Pax7	347..385	CDD:289156	4/37 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..409		8/26 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810