Protein Alignment toe and PAX6

DIOPT Version :9

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_001355839.1
• Gene: PAX6 / 5080
• HGNCID: 8620
• Length: 503
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 182/598 - (30%)
• Similarity: 255/598 - (42%)
• Gaps: 184/598 - (30%)

  Fly    16 IRVSLPGAAPAIPATATAGSQSPGAIMPMAAVPLPSHLQLLGSSAGGVGQPAAITPVSPTAATTV 80
            ||.....|||:....|..|.:|..|.: ..||...:.|..|..:.||              .|.:
Human    20 IRAPWNPAAPSQSQHAEQGGRSSAAEI-KRAVAGANRLPALSLTCGG--------------RTCL 69

  Fly    81 LAQPHSLSPSTP--ILTQGAPPAAALGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFG 143
            ..:|   ||.:.  :.|.|......|||:|..|.....              :::.:::||:..|
Human    70 WLKP---SPGSDSHVCTGGHSGVNQLGGVFVNGRPLPD--------------STRQKIVELAHSG 117

  Fly   144 LRGYDLAQHMLSQQGAVSKLL------GTLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAW 202
            .|..|:::.:....|.|||:|      |::||.. ||||||:||||.|||||.|||||.|:||||
Human   118 ARPCDISRILQVSNGCVSKILGRYYETGSIRPRA-IGGSKPRVATPEVVSKIAQYKRECPSIFAW 181

  Fly   203 EIRERLITEGVCTNATAPSVSSINRILRNRAAER----AAAEF-------ARAASYGYAIHPTHP 256
            |||:||::||||||...||||||||:|||.|:|:    |...:       .:..|:|     |.|
Human   182 EIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWG-----TRP 241

  Fly   257 --HPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQPGGSGSSYGSDGNMSSNPNSSNSNTT 319
              :|.||.|                   |.|...|...|.||
Human   242 GWYPGTSVP-------------------GQPTQDGCQQQEGG----------------------- 264

  Fly   320 HSNGHNTNSGSGCG-DSSAGSGRLSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQPK 383
               |.||||.|..| ||.....||.|                                    :.|
Human   265 ---GENTNSISSNGEDSDEAQMRLQL------------------------------------KRK 290

  Fly   384 FRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLI 448
            .:||||:|:.||::.|||||:::|||.|..||:|||:..|.|||:|||||||||||||.:::...
Human   291 LQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQ 355

  Fly   449 KQRDS------PSTSSSPTPLVNPVVSPVSPI------------------------PVPVPVAVP 483
            :::.|      |.:||..|.:..|:..|.:|:                        |:| ...:.
Human   356 RRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMP-SFTMA 419

  Fly   484 ESGQQKQPYPYSTSN-MCNTSSSSS-NSQPCNTINP---GSKMSSKTSSVSSNQHMEEPAAAVAT 543
            .:...:.|.|..||: .|...:|.| |.:..:|..|   .:.|:|:....|.       ..:...
Human   420 NNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSG-------TTSTGL 477

  Fly   544 ASPTASAPLSMGG 556
            .||..|.|:.:.|
Human   478 ISPGVSVPVQVPG 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	57/101 (56%)
		Homeobox	388..440	CDD:278475	33/51 (65%)
PAX6	NP_001355839.1	PAX	85..209	CDD:128645	63/138 (46%)
		Homeobox	295..348	CDD:395001	34/52 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810