DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toe and PAX5

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_057953.1	Gene:	PAX5 / 5079	HGNCID:	8619	Length:	391	Species:	Homo sapiens

Alignment Length:	487	Identity:	128/487 - (26%)
Similarity:	186/487 - (38%)	Gaps:	164/487 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLLGTLR 168
            |||:|..|...  |...            :.|::||:..|:|..|:::.:....|.|||:||...
Human    23 LGGVFVNGRPL--PDVV------------RQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYY 73

  Fly   169 -----PPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINRI 228
                 .||:|||||||||||.||.||.:|||:|||:||||||:||:.|.||.|.|.|||||||||
Human    74 ETGSIKPGVIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRI 138

  Fly   229 LRNRAAERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQ 293
            :|.:..:                                            ||
Human   139 IRTKVQQ--------------------------------------------PP------------ 147

  Fly   294 PGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDSRS 358
                           :.|..::|::..|.|..|...|...||:..|..:        ||.....|
Human   148 ---------------NQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSI--------SGILGITS 189

  Fly   359 PDADANRMIDIEGEDSESQDSDQPK--------FRRNR---TTFSPEQLDELEKEFDKSHYPCVN 412
            |.||.|:    ...|...|:|..|.        |.|.:   ..|:.:||:.|::.|::.||..:.
Human   190 PSADTNK----RKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDIF 250

  Fly   413 TR------EKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTPLVNPVVS-- 469
            |.      |:....:|::..          |......:.||.....:...||.|.|...|:|:
Human   251 TTTEPIKPEQTTEYSAMASL----------AGGLDDMKANLASPTPADIGSSVPGPQSYPIVTGR 305

  Fly   470 PVSPIPVP-VPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSS------KTSS 527
            .::...:| .|..||.:||.....|..|..:                 |||:.|.      :.||
Human   306 DLASTTLPGYPPHVPPAGQGSYSAPTLTGMV-----------------PGSEFSGSPYSHPQYSS 353

  Fly   528 VSSNQHMEEP---------AAAVATASPTASA 550
            .:.:.....|         :||...|:|.|:|
Human   354 YNDSWRFPNPGLLGSPYYYSAAARGAAPPAAA 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	57/100 (57%)
toe	NP_524041.2	Homeobox	388..440	CDD:278475	11/60 (18%)
PAX5	NP_057953.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PAX	16..140	CDD:128645	63/130 (48%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	19..75		18/65 (28%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	94..142		33/47 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..218		11/39 (28%)
		Pax2_C	279..389	CDD:403565	29/124 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810