Protein Alignment toe and PAX4

DIOPT Version :9

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_001353039.1
• Gene: PAX4 / 5078
• HGNCID: 8618
• Length: 351
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 132/481 - (27%)
• Similarity: 180/481 - (37%)
• Gaps: 168/481 - (34%)

  Fly   104 LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLL---- 164
            |||:|..|...              .|.::.:::.|:..|:|..|:::.:....|.|||:|
Human    12 LGGLFVNGRPL--------------PLDTRQQIVRLAVSGMRPCDISRILKVSNGCVSKILGRYY 62

  Fly   165 --GTLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINR 227
              |.|.|.| ||||||::|||.||::|.|.|.|.|.:|||||:.:|..||:||....||||||||
Human    63 RTGVLEPKG-IGGSKPRLATPPVVARIAQLKGECPALFAWEIQRQLCAEGLCTQDKTPSVSSINR 126

  Fly   228 ILRNRAAERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGAL 292
            :||                                                            ||
Human   127 VLR------------------------------------------------------------AL 131

  Fly   293 QPGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPA------LSPDS 351
            |                                .:.|..|       .||..||      |:|.|
Human   132 Q--------------------------------EDQGLPC-------TRLRSPAVLAPAVLTPHS 157

  Fly   352 GSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREK 416
            ||...|.......                    .||||.|||.|.:.|||||.:..||....|.|
Human   158 GSETPRGTHPGTG--------------------HRNRTIFSPSQAEALEKEFQRGQYPDSVARGK 202

  Fly   417 LAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPT-PLVNPVVSPVSPIPVPVPV 480
            ||..|:|.|..|:||||||||||||.:::..  :...|..|...| |.|.|.:......|..||.
Human   203 LATATSLPEDTVRVWFSNRRAKWRRQEKLKW--EMQLPGASQGLTVPRVAPGIISAQQSPGSVPT 265

  Fly   481 AVPESGQQKQPYPYSTSNMCNTSSSS---SNSQPCNTINP-----GSKMSSKTSSV------SSN 531
            |...:   .:|...|...:|..::..   |::.|...:.|     ..:.:|..|.:      ||:
Human   266 AALPA---LEPLGPSCYQLCWATAPERCLSDTPPKACLKPCWGHLPPQPNSLDSGLLCLPCPSSH 327

  Fly   532 QHMEEPAAAVATASPTASAPLSMGGE 557
            .|:...:.:.|...|  ..||..|.|
Human   328 CHLASLSGSQALLWP--GCPLLYGLE 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	47/101 (47%)
		Homeobox	388..440	CDD:278475	30/51 (59%)
PAX4	NP_001353039.1	PAX	5..129	CDD:128645	53/131 (40%)
		Homeobox	174..226	CDD:306543	30/51 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910