Protein Alignment toe and PAX2

DIOPT Version :9

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_003981.3
• Gene: PAX2 / 5076
• HGNCID: 8616
• Length: 432
• Species: Homo sapiens
• Alignment Length: 514
• Identity: 141/514 - (27%)
• Similarity: 192/514 - (37%)
• Gaps: 171/514 - (33%)

  Fly   104 LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLLGTLR 168
            |||:|..|...  |...            :.|::||:..|:|..|:::.:....|.|||:||...
Human    23 LGGVFVNGRPL--PDVV------------RQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYY 73

  Fly   169 -----PPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINRI 228
                 .||:|||||||||||.||.||.:|||:|||:||||||:||:.||:|.|.|.|||||||||
Human    74 ETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRI 138

  Fly   229 LRNRAAERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQ 293
            :|.:..:              ..||| |....:..|.|.|        ...|....|..:..:..
Human   139 IRTKVQQ--------------PFHPT-PDGAGTGVTAPGH--------TIVPSTASPPVSSASND 180

  Fly   294 PGGSGSSYGSDGNMSSNPNSSNSN--TTHSNGHNTNSGSG------CGDSSAGSGRLSLPALSPD 350
            |.||.|..|..|...||......:  ..:::..:...|.|      ..|.|.|    |:|
Human   181 PVGSYSINGILGIPRSNGEKRKRDEVEVYTDPAHIRGGGGLHLVWTLRDVSEG----SVP----- 236

  Fly   351 SGSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCV---- 411
                               .|:.....||.:...|.:  ||:.:||:.|::.|::..||.|
Human   237 -------------------NGDSQSGVDSLRKHLRAD--TFTQQQLEALDRVFERPSYPDVFQAS 280

  Fly   412 --------NTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTPLVNPVV 468
                    |.....|....|.|.:                          .|.|:|..|.:...|
Human   281 EHIKSEQGNEYSLPALTPGLDEVK--------------------------SSLSASTNPELGSNV 319

  Fly   469 SPVSPIPVPV------------PVAVPESGQQKQPYPYST-SNMCNTSSSSSNSQPCNTINPGSK 520
            |.....||..            |..||.:||..  ||.|| :.|.                |||:
Human   320 SGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGS--YPTSTLAGMV----------------PGSE 366

  Fly   521 MSSKTSS----VSSNQ--HMEEPAAAVATASPTASAPLSMGGENSAFRALPMTLPMPMT 573
            .|....|    .:.|:  ....||..:    |...||           .||: ||:|||
Human   367 FSGNPYSHPQYTAYNEAWRFSNPALLM----PPPGAP-----------PLPL-LPLPMT 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	57/100 (57%)
		Homeobox	388..440	CDD:278475	13/63 (21%)
PAX2	NP_003981.3	PAX	16..140	CDD:128645	63/130 (48%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75		18/65 (28%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		33/47 (70%)
		homeodomain	255..>278	CDD:412151	9/22 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	304..325		6/46 (13%)
		Pax2_C	305..>390	CDD:403565	24/102 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810