DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toe and Tlx3

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_573065.4	Gene:	Tlx3 / 497881	RGDID:	1564190	Length:	291	Species:	Rattus norvegicus

Alignment Length:	267	Identity:	69/267 - (25%)
Similarity:	97/267 - (36%)	Gaps:	74/267 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 HPHPYTSF-----------PTWPAHHPLWGAVPLATPPGGGPAGAGGALQP--GGSGSSYGSDGN 306
            |||...||           .:.||.....||..|..||||.|..|..:|..  .|.|:.:...|:
  Rat    11 HPHEPISFGIDQILNSPDQDSAPAPRGPDGASYLGGPPGGRPGAAYPSLPASFAGLGAPFEDAGS 75

  Fly   307 MSSNPNSSNSNTTHSNGHNTNSGS------------GCGDSSAGSGRLSLP-------------- 345
            .|.|.:.:.:.......|....|:            ....:.:..|.|:.|
  Rat    76 YSVNLSLAPAGVIRVPAHRPLPGAVPPPLPSALPAMPSVPTVSSLGGLNFPWMESSRRFVKDRFT 140

  Fly   346 ---ALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSH 407
               ||:|.:.:|....|                .|:...||.::.||:||..|:.||||.|.:..
  Rat   141 AAAALTPFTVTRRIGHP----------------YQNRTPPKRKKPRTSFSRVQICELEKRFHRQK 189

  Fly   408 YPCVNTREKLAARTALSEARVQVWFSNRRAKWRRH------------QRVNLIKQRD----SPST 456
            |.....|..||....:::|:|:.||.|||.||||.            .|:.|..|.|    |.:.
  Rat   190 YLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLND 254

  Fly   457 SSSPTPL 463
            |..|.||
  Rat   255 SIQPDPL 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	22/51 (43%)
Tlx3	XP_573065.4	Homeobox	169..223	CDD:395001	23/53 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910