DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and E5

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_524825.1	Gene:	E5 / 45396	FlyBaseID:	FBgn0008646	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	481	Identity:	116/481 - (24%)
Similarity:	168/481 - (34%)	Gaps:	152/481 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PTRTTAAIRVSLPGAAPAIPATATAGSQSPGAIMPMAAVPLPSHLQLLGSSAGGVGQPAAITPVS 73
            ||....:...|:..::.::.|::|..:.:  :..|..|..:.|   ::|.|:         |..:
  Fly    16 PTSPFVSSSSSVAASSTSVSASSTVSASA--SSKPKLAFSIDS---IVGESS---------TRSA 66

  Fly    74 PTAATTVLA-QPHSLSPSTPILTQGAPPAAALGGIFCGGSAAAGPGAAAAAATNLNALASQHRLL 137
            |...:.:.: .|.|.||::|..|..:......|.|:|                      .:...|
  Fly    67 PLRVSVISSPPPRSESPASPTNTNNSGRRTPRGYIYC----------------------RRRDSL 109

  Fly   138 ELSRFGLRGYDLAQHMLSQQGAVSKLLGTLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAW 202
            :.||            ..|:..||:   :..||.  .|..|..|..|..|........||...
  Fly   110 DRSR------------SPQRSPVSR---SPSPPN--AGGNPAAAGNTAKSGDPSSGTGNPPTL-- 155

  Fly   203 EIRERLITEGVCTNATAPSVSSI-NRILRNRAAER--------------AAAEFARAASYGYAIH 252
             ||...:        .||:::.| ||...|..|.|              .||:|..||:.
  Fly   156 -IRPLPL--------PAPNLALIGNRTSPNAMAVRMAGPPHPPSQPPPFLAAQFQMAAAL----- 206

  Fly   253 PTHPHPYTS---------FPTWPAH--HPLWGAVPLATPPGGGPAGAGGALQPGGSGSSYGSDGN 306
             .|.|....         .||.|.|  ||       ..|||..|.|    :.|||
  Fly   207 -AHHHQQQQQQQQQQLPPVPTGPPHGPHP-------HLPPGQIPLG----IFPGG---------- 249

  Fly   307 MSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDSR-SPDADANRMIDIE 370
                |:.         ||....|.....|:....|.|.| |.|...||..| .|....|.:.
  Fly   250 ----PHP---------GHPPPHGHHPFGSAPHLIRDSYP-LYPWLLSRHGRIFPRFPGNFLF--- 297

  Fly   371 GEDSESQDSDQP--KFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFS 433
                      ||  |.:|.||.|||.||.:||..|:.:||.....|::||...:|:|.:|:|||.
  Fly   298 ----------QPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQ 352

  Fly   434 NRRAKWRRHQRVNLIKQRDSPSTSSS 459
            |||.|.:|.|:    :..|...|.|:
  Fly   353 NRRTKHKRMQQ----EGGDGSDTKSN 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	22/96 (23%)
toe	NP_524041.2	Homeobox	388..440	CDD:278475	25/51 (49%)
E5	NP_524825.1	Homeobox	307..359	CDD:278475	25/51 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I3587
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910