DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toe and cdx1a

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_998001.2	Gene:	cdx1a / 405762	ZFINID:	ZDB-GENE-050510-1	Length:	228	Species:	Danio rerio

Alignment Length:	264	Identity:	71/264 - (26%)
Similarity:	98/264 - (37%)	Gaps:	91/264 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 ASYGYA---IHPTHPH----PYTSFPTWPAHHPLWGAVPLATPPGGGPA------GAGGALQPG- 295
            |.||..   ::.:.||    |...:|.:..:||             |||      ..|.:..||
Zfish    10 AMYGNPARHLNLSQPHLNVYPSAPYPDYSGYHP-------------GPALGNDLHHTGSSWSPGF 61

  Fly   296 GSGSS------YGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSR 354
            |.||.      ||                 |..||                  ||||    :|..
Zfish    62 GPGSRDDWPPLYG-----------------HGTGH------------------SLPA----NGVE 87

  Fly   355 DSRSPDADANRMIDIEGEDSESQD----SDQP-----KFR---RNRTTFSPEQLDELEKEFDKSH 407
            .|..|..|...:.....:..|.||    |..|     |.|   :.|..:|..|..||||||..|.
Zfish    88 VSVLPSVDQGLLSGAPVDREEPQDWMRRSAVPTNPGGKTRTKDKYRVVYSDVQRLELEKEFHFSR 152

  Fly   408 YPCVNTREKLAARTALSEARVQVWFSNRRAKWRR--HQRVNLIKQRDS-----PSTSSSPTPLVN 465
            |..:..:.:||....|||.:|::||.|||||.|:  .:|:..::|..|     .:.|||.:.|:.
Zfish   153 YITIRRKAELAGTLNLSERQVKIWFQNRRAKERKMNKKRLQQVQQSSSGLANTTTVSSSDSGLMT 217

  Fly   466 PVVS 469
            ..:|
Zfish   218 DNIS 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	24/51 (47%)
cdx1a	NP_998001.2	Caudal_act	11..115	CDD:282574	33/155 (21%)
		COG5576	<122..227	CDD:227863	35/100 (35%)
		Homeobox	133..185	CDD:278475	24/51 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910