DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and pitx3

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_991238.1	Gene:	pitx3 / 402974	ZFINID:	ZDB-GENE-041229-4	Length:	293	Species:	Danio rerio

Alignment Length:	283	Identity:	85/283 - (30%)
Similarity:	106/283 - (37%)	Gaps:	109/283 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 DSSAGSGRLSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQP-------KFRRNRTTF 391
            ||.|.|..|||    .|||: ....|........|.|.......|...|       |.||.||.|
Zfish     8 DSEARSPALSL----SDSGT-PQHDPGCKGQDNSDTEKSHQNHTDESNPEDGSLKKKQRRQRTHF 67

  Fly   392 SPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWR---RHQRVNLIKQR-- 451
            :.:||.|||..|.::.||.::|||::|..|.|:||||:|||.|||||||   |:|:..|.|..
Zfish    68 TSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFG 132

  Fly   452 ----------------------DSPSTSSSP--------------TPLVN-PVVSPVSPIP---- 475
                                  .:.|.:|||              :||.: |:.||.|.||
Zfish   133 AQFNGLMQPYDDMYSGYSYNNWATKSLASSPLSAKSFPFFNSMNVSPLSSQPMFSPPSSIPSMNM 197

  Fly   476 ----VPVPVA-VPESGQQKQ---------------------PY-----PYSTSNMCNTSSSS--- 506
                ||..|| ||.||....                     ||     ||...:.||:|.:|
Zfish   198 ASSMVPSAVAGVPGSGLNNLGNLNNLNSPTLNSAAVSAAACPYATTAGPYMYRDTCNSSLASLRL 262

  Fly   507 -----------------SNSQPC 512
                             ||..||
Zfish   263 KAKQHANFAYPAVQNPVSNLSPC 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	29/51 (57%)
pitx3	NP_991238.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..69		21/65 (32%)
		Cnd2	18..>79	CDD:303063	20/65 (31%)
		Homeobox	64..116	CDD:278475	29/51 (57%)
		OAR	251..268	CDD:281777	4/16 (25%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	255..268		2/12 (17%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O35160	260..264		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910