DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and msx2

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_002936749.1	Gene:	msx2 / 394987	XenbaseID:	XB-GENE-852974	Length:	256	Species:	Xenopus tropicalis

Alignment Length:	207	Identity:	59/207 - (28%)
Similarity:	86/207 - (41%)	Gaps:	55/207 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   331 GCGDSSAGSGRLSLPALSPDSGSRDSRSPD--ADANRMIDIEGEDSE-----SQD----SDQPKF 384
            |...|:|||....|     ..|.|||.||.  ........::.|:||     |:|    |..|:.
Frog    58 GVDASAAGSTPRHL-----HMGIRDSPSPPGLTKTFETSSVKSENSEDGTTWSKDGGSYSPPPRH 117

  Fly   385 --------------RRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNR 435
                          |:.||.|:..||..||::|.:..|..:..|.:.::...|:|.:|::||.||
Frog   118 LSPSTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNR 182

  Fly   436 RAKWRRHQRVNLIKQRDS-----PSTSSSPTPLVNPVVS------------PVSPIPVPVPVAVP 483
            |||.:|.|...:.|.:.:     |...|.|.|:.:|:.:            ||.|||   ||
Frog   183 RAKAKRLQEAEIEKLKMAAKPILPPGFSIPFPINSPIQAASLYGSSYQFHRPVLPIP---PV--- 241

  Fly   484 ESGQQKQPYPYS 495
              |....|..||
Frog   242 --GLYATPVGYS 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	20/51 (39%)
msx2	XP_002936749.1	Homeobox	134..188	CDD:365835	20/53 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910