DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and vax2

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_919390.1	Gene:	vax2 / 373869	ZFINID:	ZDB-GENE-030904-8	Length:	307	Species:	Danio rerio

Alignment Length:	284	Identity:	79/284 - (27%)
Similarity:	120/284 - (42%)	Gaps:	32/284 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 DGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLP---ALSPDSGSRDSRSP----DA 361
            ||......:..:::.....|..:.|.:..|:.|........|   |.:|.|.|.|....    |.
Zfish    10 DGIAEDRNHCGSNSLCRDRGRESKSRTEVGNRSPVQSSTDTPGTSASTPTSSSEDGHDKLLGVDP 74

  Fly   362 DANRMI---DIEGEDSE-----SQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLA 418
            |..|.|   |.:|...|     ..|.|:||  |.||:|:.|||..||.||.:..|.....|.:||
Zfish    75 DYCRRILVRDAKGTIREIVLPKGLDLDRPK--RTRTSFTAEQLYRLELEFQRCQYVVGRERTELA 137

  Fly   419 ARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTPLVNPVVSPVSPIPVPVPVAVP 483
            .:..|||.:|:|||.|||.|.::.|..:..| |.|.::.|..|..:..::.....:.||.|   |
Zfish   138 RQLNLSETQVKVWFQNRRTKQKKDQTKDTDK-RSSSTSESLATCNILRLLEQGRLLSVPAP---P 198

  Fly   484 ESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSSKTSSVSS------NQHMEEPAAAVA 542
            .:.....|:|.:.|.:.:.|.|:|:....:|..||:...:...|:||      :..:..|..::.
Zfish   199 PNPLLAHPHPGNGSLLGSPSVSTSSGVSSSTTPPGAGSGTFGLSLSSLSGTPPSPRLGVPPPSLC 263

  Fly   543 TASPTASA-----PLSMGGENSAF 561
            ...|..|.     |...|...|||
Zfish   264 FTMPLLSGAHHELPSGYGCGTSAF 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	25/51 (49%)
vax2	NP_919390.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70		12/59 (20%)
		Homeobox	106..159	CDD:278475	25/52 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..175		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..254		14/59 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910