DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toe and B-H2

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_523386.1	Gene:	B-H2 / 32723	FlyBaseID:	FBgn0004854	Length:	645	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	173/759 - (22%)
Similarity:	258/759 - (33%)	Gaps:	241/759 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TSTSPGPTRTTAAIRVSLP-GAAPAIPATATAGSQSPGAIMPMAAVPLPSHLQLLGSSAGGVGQP 66
            |:..|..:.||||     | |:||    :|||  ..|.|:                  .||:.:|
  Fly     2 TTMPPEMSATTAA-----PVGSAP----SATA--HHPAAV------------------GGGMPRP 37

  Fly    67 AAITPVSPTAATTVLAQPHSLSPSTPILTQGAPPAAALGGIFCGGSAAAGPGAAAAAATNL---N 128
            |:....|.|...|......|....|.||. ||..|:|.........|||..|....:.|:.   .
  Fly    38 ASPAVGSNTTTATATTATRSRFMITDILA-GAAAASAAAAAAAAALAAASSGGGRGSPTDSEREQ 101

  Fly   129 ALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLLGTLRPPGLIGGSKPKVATPTVVSKIEQYK 193
            :|.:||......:.....:...|.....|.|.                            ::||.
  Fly   102 SLVAQHHHHHQQQQQHHHHQQQQQQQQHQQAA----------------------------LQQYI 138

  Fly   194 RENPTIFAWEIRERLITEGVCTNATAPSVSSINRILRNRAAERAAAEFARAASYGYAIHPTHPHP 258
            .:...:..:| |||                     .|.|..|......:...:..||.||..||.
  Fly   139 VQQQQLLRFE-RER---------------------EREREREHYRERHSPPGNNPYAHHPMPPHL 181

  Fly   259 YTSFPTWPAH---------------HPLWGAVPLATPP-----------GGGPAGAGGAL----- 292
            ...||  |||               ||....:.|....           .|.||.....|
  Fly   182 LAHFP--PAHYAVLQQQQQQQQQQQHPHPHHLQLERERLEALHRHGHGLTGDPAQHLSHLSHLSH 244

  Fly   293 -----------------------QPGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGD 334
                                   |.||:|.:..::.|.||:.:::|:|..:|...|:|..||...
  Fly   245 QQHHPHLHHPMHDERSRSPLMLQQLGGNGGNNNNNNNNSSSASNNNNNNNNSASANSNIISGNSS 309

  Fly   335 SS-----AGSGRLSL--PALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQ----------- 381
            ||     :|:|.:.|  |. |..||.:.|...|:|::   |..|:|.:..||.:
  Fly   310 SSNNNNGSGNGNMLLGGPG-SSISGDQASTIDDSDSD---DCGGKDDDGDDSMKNGSSANGDSSS 370

  Fly   382 -------PKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKW 439
                   .|.|:.||.|:..||..|||.|::..|..|..|.:||.:..||:.:|:.|:.|||.||
  Fly   371 HLSLSLSKKQRKARTAFTDHQLQTLEKSFERQKYLSVQDRMELANKLELSDCQVKTWYQNRRTKW 435

  Fly   440 RRHQRVNL----------IKQR----DSPSTSSSPTPLVNPVVSPVSPIPVPVPV----AVPESG 486
            :|...|.|          ..||    .:|..|:.|........||....|..:.:    |...:.
  Fly   436 KRQTAVGLELLAEAGNYAAFQRLYGGATPYLSAWPYAAAAAAQSPHGATPSAIDIYYRQAAAAAA 500

  Fly   487 QQKQPYPYSTSNMCNTSSSSSNSQPCNTINP------------GSKMSSKTSSVSSNQHMEEPAA 539
            .||...| ::..|..:|.....|.|.....|            .:..::..|:.:..|..:.|||
  Fly   501 MQKPSLP-ASYRMYQSSIPPGMSLPGMPAPPPPGAAPMLSGYYAAAAAAAASAGAQQQQQQPPAA 564

  Fly   540 AVATA-SPTASAPLSMGGENSAFRALPMTLPMPMTLPTASAAAFALSFARQYIAKYMGTPLNLGH 603
            :.:.| |.:|::.......:|:.|...:| |.|                          |||  .
  Fly   565 SRSPATSQSANSEADCERTSSSSRQRLIT-PSP--------------------------PLN--P 600

  Fly   604 GSSP----IQAQSGRDHQSE-------EREYEDEQEEEEVINVE 636
            ||.|    |..:..|:...|       |||.|.::::||.:.:|
  Fly   601 GSPPHRERINEEEDRERDEERDIERERERERERDEDDEEELALE 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	10/95 (11%)
toe	NP_524041.2	Homeobox	388..440	CDD:278475	22/51 (43%)
B-H2	NP_523386.1	Homeobox	384..436	CDD:278475	22/51 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I3587
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910