DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toe and HOXD3

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_008829.3	Gene:	HOXD3 / 3232	HGNCID:	5137	Length:	432	Species:	Homo sapiens

Alignment Length:	382	Identity:	96/382 - (25%)
Similarity:	145/382 - (37%)	Gaps:	101/382 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 SYGYAI-HPTHPHPY------TSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQPGGSGSSYGS 303
            :|||:. |..:|.|.      |.:|  .:...:..:.||..|...|....|..::| |:|:|.|.
Human    40 TYGYSTPHQPYPPPAAASSLDTDYP--GSACSIQSSAPLRAPAHKGAELNGSCMRP-GTGNSQGG 101

  Fly   304 DGNMSSNPNSSNSN----------TTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDSRS 358
            .|  .|.|...||.          .|......||.|.|            :||..|..|...| |
Human   102 GG--GSQPPGLNSEQQPPQPPPPPPTLPPSSPTNPGGG------------VPAKKPKGGPNAS-S 151

  Fly   359 PDADANRMI-----------------DIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKS 406
            ..|..::.|                 ...||..|.:....|..:|.||.::..||.||||||..:
Human   152 SSATISKQIFPWMKESRQNSKQKNSCATAGESCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFN 216

  Fly   407 HYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSP--TPLVNPVVS 469
            .|.|...|.::|....|:|.::::||.|||.|:::.|:...|..  ||: |.||  :|.:.....
Human   217 RYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAKGILH--SPA-SQSPERSPPLGGAAG 278

  Fly   470 PVS------PIP-----VPVPVAVPES------------------GQQK-------QPYPYSTSN 498
            .|:      |:|     .|.|.|..:|                  .|||       :|:|.: ||
Human   279 HVAYSGQLPPVPGLAYDAPSPPAFAKSQPNMYGLAAYTAPLSSCLPQQKRYAAPEFEPHPMA-SN 342

  Fly   499 MCNTSSSSSNSQPC----NTINPGSKMSSKTSSVSSNQHMEEPAAAVATASPTASAP 551
            ....:|::....|.    |.:   ..|:..:..|.:..|:..|::|....|..|..|
Human   343 GGGFASANLQGSPVYVGGNFV---ESMAPASGPVFNLGHLSHPSSASVDYSCAAQIP 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	22/51 (43%)
HOXD3	NP_008829.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..62		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..197		32/144 (22%)
		Antp-type hexapeptide	160..165		1/4 (25%)
		Homeobox	198..250	CDD:306543	22/51 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..280		8/29 (28%)
		DUF4074	369..430	CDD:315871	7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910