DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Hoxc5

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001101586.1	Gene:	Hoxc5 / 315341	RGDID:	1307584	Length:	222	Species:	Rattus norvegicus

Alignment Length:	230	Identity:	52/230 - (22%)
Similarity:	92/230 - (40%)	Gaps:	66/230 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 YTSFPTWPAHHP-----------------LWGAVPLAT--PPGGGPAGAGGALQPGGSGSSYGSD 304
            |...|..||::.                 .:|.:.|:.  ||            |..|.|.:|.|
  Rat    10 YKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLDLSITFPP------------PAPSNSLHGVD 62

  Fly   305 GNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDSRSP--DADANRMI 367
              |::||.:      |.:....::.:..|.:   .||.....|:|...|:.:..|  :..|....
  Rat    63 --MAANPRA------HPDRPACSAAAAPGHA---LGRDEAAPLNPGMYSQKAARPALEERAKSSG 116

  Fly   368 DIEGEDSE-------SQDSDQPKF---------------RRNRTTFSPEQLDELEKEFDKSHYPC 410
            :|:.|.::       ||....|:.               :|:||:::..|..||||||..:.|..
  Rat   117 EIKEEQAQTGQPAGLSQPPAPPQIYPWMTKLHMSHETDGKRSRTSYTRYQTLELEKEFHFNRYLT 181

  Fly   411 VNTREKLAARTALSEARVQVWFSNRRAKWRRHQRV 445
            ...|.::|....|:|.::::||.|||.||::..::
  Rat   182 RRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKM 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	20/51 (39%)
Hoxc5	NP_001101586.1	COG5373	65..>142	CDD:227665	16/85 (19%)
Hoxc5	NP_001101586.1	Homeobox	158..212	CDD:395001	21/53 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910