DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and nkx2.7

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_571494.1	Gene:	nkx2.7 / 30694	ZFINID:	ZDB-GENE-990415-179	Length:	269	Species:	Danio rerio

Alignment Length:	216	Identity:	54/216 - (25%)
Similarity:	84/216 - (38%)	Gaps:	46/216 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 SGCGDSSAGSGRLSLPALSP-----DSGSRDSRSPDADANRMIDIEGEDSES-QDSDQPKFRRN- 387
            |.||              ||     |:....|..|..|::    ...::.|: ::..:.:.||.
Zfish    81 SSCG--------------SPTEEEMDANEETSMCPFTDSS----YSSKNGETLREKPKQRLRRKP 127

  Fly   388 RTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRD 452
            |..||..|:.|||:.|.:..|.....|:.||....|:..:|::||.|||.|.:|       :::|
Zfish   128 RVLFSQTQVFELERRFKQQRYLSAPERDHLALALKLTSTQVKIWFQNRRYKCKR-------QRQD 185

  Fly   453 SPSTSSSPTPLVNPVV----SPVSPIPVPVPVAVPESGQQ----KQPYPYSTSNMCNTSSSSSNS 509
            .....:.|..:..||:    .|....|..|.|:.|.:...    ..||      .||.:|..|.:
Zfish   186 KSLELAGPRRVAVPVLVRDGKPCHGAPYNVTVSYPYNNYYNSYGNNPY------HCNFTSVPSFA 244

  Fly   510 QPCNTINPGSKMSSKTSSVSS 530
            ......|....|:..|.||.|
Zfish   245 NTSQIPNHFVDMNLTTGSVDS 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	20/51 (39%)
nkx2.7	NP_571494.1	COG5576	87..210	CDD:227863	33/133 (25%)
nkx2.7	NP_571494.1	Homeobox	127..180	CDD:278475	20/52 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910