DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toe and dlx4a

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_571375.1	Gene:	dlx4a / 30561	ZFINID:	ZDB-GENE-980526-73	Length:	250	Species:	Danio rerio

Alignment Length:	267	Identity:	66/267 - (24%)
Similarity:	108/267 - (40%)	Gaps:	70/267 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 AERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQPGGSG 298
            ::.|..||    |:||..|..| .|..|.    ||:|:.|.      ..|..:....|..||  .
Zfish    16 SKSAFLEF----SHGYQSHQQH-SPGVSH----AHYPVHGL------HQGAHSQYDAAFSPG--A 63

  Fly   299 SSYGSDGNMSSNPNSSNSNTTHSN-------GHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDS 356
            :||       |.|.:.:.:|.|.:       .||:..|.                         |
Zfish    64 ASY-------SRPLAYHYSTAHHHPGAYLPYQHNSAVGY-------------------------S 96

  Fly   357 RSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAART 421
            |..|||:.:...||..:.......: |.|:.||.:|..||..|.:.|.::.|..:..|..|||:.
Zfish    97 RVEDADSEKQSSIESGEIRLNGKGK-KIRKPRTIYSSLQLQALNQRFQQTQYLALPERADLAAKL 160

  Fly   422 ALSEARVQVWFSNRRAKWRRHQRVNLIKQRDS-------PSTSSSPTPLVNPVVSPVSPIPVPVP 479
            .|::.:|::||.|:|:|:::     ::|...|       .:.|:|..| .:|.:.|:..:.:|..
Zfish   161 GLTQTQVKIWFQNKRSKYKK-----IMKHGSSGPEGEHLQAASASGAP-CSPGMPPLWDVSMPSK 219

  Fly   480 VAVPESG 486
            .|...||
Zfish   220 GAPIHSG 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	19/51 (37%)
dlx4a	NP_571375.1	COG5576	98..206	CDD:227863	31/114 (27%)
		Homeobox	126..179	CDD:278475	19/52 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..202		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910