DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and rx1

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_571300.2	Gene:	rx1 / 30472	ZFINID:	ZDB-GENE-990415-236	Length:	330	Species:	Danio rerio

Alignment Length:	231	Identity:	83/231 - (35%)
Similarity:	109/231 - (47%)	Gaps:	62/231 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 GAVPLATPPGGGPAGAGGAL----QPGGSGSSYG-----SDGNMSSNPNSSNSNTTHSNGHNTNS 328
            ||..:|...||...|..|.|    ||      ||     .||  |..|..          |:.:.
Zfish    56 GANAVAHKVGGESLGEPGKLDQRVQP------YGHLPPLRDG--SEQPTF----------HDADM 102

  Fly   329 GSGCGDSSAGSGRLSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQP--KFRRNRTTF 391
            .|...|...|..|.::.:        ||:|||               |.|.:||  |.|||||||
Zfish   103 FSNKCDGDLGDLRKAIES--------DSKSPD---------------SADGEQPKKKHRRNRTTF 144

  Fly   392 SPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRV--NLIKQRDSP 454
            :..||.|||:.|:|||||.|.:||:||.:..|.|.||||||.||||||||.:::  :.:|..|||
Zfish   145 TTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKIDASTMKLHDSP 209

  Fly   455 STSSSPTPLVNPVVSPVSP-------IPVPVPVAVP 483
            ..|.: .|.::|.|.|::.       :|.|:..|.|
Zfish   210 MLSFN-RPSMHPTVGPMNNSLPLDPWLPSPLSSATP 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	33/51 (65%)
rx1	NP_571300.2	Octapeptide motif	37..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..104		13/55 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..142		13/46 (28%)
		Homeobox	141..193	CDD:278475	33/51 (65%)
		OAR	302..318	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319
		Nuclear localization signal. /evidence=ECO:0000255	312..316
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910