DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and hoxb1b

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_571217.2	Gene:	hoxb1b / 30374	ZFINID:	ZDB-GENE-980526-290	Length:	307	Species:	Danio rerio

Alignment Length:	306	Identity:	78/306 - (25%)
Similarity:	109/306 - (35%)	Gaps:	93/306 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 YAIHPTHPHPYTS----FPTWPAHHPLWGAVPLATPPGGGPAGAGGALQPG---GSGSSYGSDGN 306
            |.|:....:.|:|    ||....:.|...|...:..|.|.|.| |......   ..|:||....:
Zfish     7 YTIYNRGSNTYSSKVGCFPVEQEYLPSACASTNSYIPEGRPVG-GNTFTSAPHETHGTSYAQIQS 70

  Fly   307 MSSNPNSSNSNTTHSN------------GH---------------------------NTNSGSGC 332
            ...:.|.....|.|||            ||                           .|.|.|.|
Zfish    71 QPFHLNVDMGKTGHSNFCKQTRPPHSDYGHQHVLTQADDHMRLQSPGFSVVNMGANIGTYSESNC 135

  Fly   333 GDSSAGSGRLSLPAL-SPD-----SGSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRN---- 387
            ...|..:......|. .|:     |.|:...|||:|::...:|:    ::...|..|.:||
Zfish   136 RPGSVSASHYQSYAYGEPEPHGYGSFSKYQVSPDSDSDSKTNIK----QAPTFDWMKVKRNPPKT 196

  Fly   388 ---------------RTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRA 437
                           ||.|:.:||.||||||..:.|.....|.::||...|:|.:|::||.|||.
Zfish   197 VKVAEYGIHGQQNIIRTNFTTKQLTELEKEFHFNKYLTRARRVEVAATLELNETQVKIWFQNRRM 261

  Fly   438 KWRRHQ---------RVNLIK--QRDSPSTSSSPTPLVNPVVSPVS 472
            |.::.:         ||.|..  |....||||||.      .||.|
Zfish   262 KQKKREKEGTAPVIKRVTLCSSGQNADHSTSSSPG------ASPTS 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	24/51 (47%)
hoxb1b	NP_571217.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..178		6/18 (33%)
		Antp-type hexapeptide	183..188		1/4 (25%)
		Homeobox	212..264	CDD:306543	24/51 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..307		13/43 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910