DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and hoxd3a

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_571200.1	Gene:	hoxd3a / 30349	ZFINID:	ZDB-GENE-990415-120	Length:	396	Species:	Danio rerio

Alignment Length:	417	Identity:	100/417 - (23%)
Similarity:	159/417 - (38%)	Gaps:	84/417 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 FARAASYGYAIHPTH--------PHPYTSFPTWPAHHPLWGAVPLATPPGGG-------PAGAGG 290
            :.::.||.|.  |||        .:.|.| |..|....   :|..||...|.       |:.:.|
Zfish    18 YPKSDSYTYG--PTHQGFSSSSIENDYQS-PICPIQTT---SVRQATHKNGDINGSCMRPSASQG 76

  Fly   291 ALQPGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPD--SGS 353
            ..||........:....:|:|:.|.::|......::|     |.|:|      .|.:|..  ...
Zfish    77 NSQPESISEQQQAAPLAASSPSPSTNSTQKKKSPSSN-----GSSTA------TPVISKQIFPWM 130

  Fly   354 RDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLA 418
            :::|......:......||..:.:....|..:|.||.::..||.||||||..:.|.|...|.::|
Zfish   131 KETRQNAKQKSTNCPAAGETCDDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMA 195

  Fly   419 ARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSP---STSSSPTPLVN----------PVVSP 470
            ....|:|.::::||.|||.|:::.|:...|..  ||   |...|| ||..          |.|:.
Zfish   196 NLLNLTERQIKIWFQNRRMKYKKDQKSKGIMH--SPLGHSPDRSP-PLSGSNHIGYSGQLPNVNS 257

  Fly   471 VS-PIPVPVPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSSKTSSVSSNQHM 534
            :| ..|.|...|.|:.               |....::.:.|.....|..|   :......:.|.
Zfish   258 LSYDAPSPPSFAKPQQ---------------NIYGLAAYTAPLGGCIPQQK---RYPGTEYDHHS 304

  Fly   535 EEPAAAVATASPTASAPLSMGGENSAFRALPMTLPMPMT--LPTASAAAFALSFARQYIAKYMGT 597
            .:...:.|.|: ..|:|:.:||  :...::|.:.||...  ||..|:|:...|.|.|       .
Zfish   305 MQGNGSFANAN-LQSSPVYVGG--NFVDSMPASGPMFNLGHLPHPSSASVDYSCAAQ-------I 359

  Fly   598 PLNLGHG---SSPIQAQSGRDHQSEER 621
            |.|..||   ..|........|.|:.|
Zfish   360 PGNHHHGPCDPHPTYTDLSSHHASQGR 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	22/51 (43%)
hoxd3a	NP_571200.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..163		32/161 (20%)
		Abdominal-A	116..237	CDD:332641	36/128 (28%)
		Antp-type hexapeptide	126..131		0/4 (0%)
		Homeobox	165..217	CDD:306543	22/51 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..246		9/29 (31%)
		DUF4074	333..394	CDD:315871	17/61 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..396		6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910