DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Pax2

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	XP_006231505.2	Gene:	Pax2 / 293992	RGDID:	1305568	Length:	432	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	143/519 - (27%)
Similarity:	191/519 - (36%)	Gaps:	181/519 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLLGTLR 168
            |||:|..|...  |...            :.|::||:..|:|..|:::.:....|.|||:||...
  Rat    23 LGGVFVNGRPL--PDVV------------RQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYY 73

  Fly   169 -----PPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINRI 228
                 .||:|||||||||||.||.||.:|||:|||:||||||:||:.||:|.|.|.|||||||||
  Rat    74 ETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRI 138

  Fly   229 LRNRAAERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQ 293
            :|.:..:              ..||| |....:..|.|.|        ...|....|..:..:..
  Rat   139 IRTKVQQ--------------PFHPT-PDGAGTGVTAPGH--------TIVPSTASPPVSSASND 180

  Fly   294 PGGSGSSYGSDGNMSSNPNSSN-------SNTTHSNGHNTNSGSG------CGDSSAGSGRLSLP 345
            |.||.|..|..|...||.....       ::..|..|     |.|      ..|.|.|    |:|
  Rat   181 PVGSYSINGILGIPRSNGEKRKREEVEVYTDPAHIRG-----GGGLHLVWTLRDVSEG----SVP 236

  Fly   346 ALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPC 410
                                    .|:.....||.:...|.:  ||:.:||:.|::.|::..||.
  Rat   237 ------------------------NGDSQSGVDSLRKHLRAD--TFTQQQLEALDRVFERPSYPD 275

  Fly   411 V------------NTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTPL 463
            |            |.....|....|.|.:                          .|.|:|..|.
  Rat   276 VFQASEHIKSEQGNEYSLPALTPGLDEVK--------------------------SSLSASTNPE 314

  Fly   464 VNPVVSPVSPIPVPV------------PVAVPESGQQKQPYPYST-SNMCNTSSSSSNSQPCNTI 515
            :...||.....||..            |..||.:||..  ||.|| :.|.
  Rat   315 LGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGS--YPTSTLAGMV--------------- 362

  Fly   516 NPGSKMSSKTSS----VSSNQ--HMEEPAAAVATASPTASAPLSMGGENSAFRALPMTLPMPMT 573
             |||:.|....|    .:.|:  ....||..:    |...||           .||: ||:|||
  Rat   363 -PGSEFSGNPYSHPQYTAYNEAWRFSNPALLM----PPPGAP-----------PLPL-LPLPMT 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	57/100 (57%)
toe	NP_524041.2	Homeobox	388..440	CDD:278475	13/63 (21%)
Pax2	XP_006231505.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810