DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toe and Mixl1

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_038757.1	Gene:	Mixl1 / 27217	MGIID:	1351322	Length:	231	Species:	Mus musculus

Alignment Length:	301	Identity:	78/301 - (25%)
Similarity:	111/301 - (36%)	Gaps:	94/301 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 AAERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQPGGS 297
            ||.....:||..|               :||.:||.||....:|...|..|.||....:..|..:
Mouse     3 AAGSQQLQFAEGA---------------AFPIFPAAHPGGQLLPAMRPASGLPAAPHDSRAPAAT 52

  Fly   298 GSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPA-LSPDSGSRDSRSPDA 361
                      ...||..:|.|..:                       || |.|...|:.|.:|.|
Mouse    53 ----------QCFPNRDSSPTAQT-----------------------PAGLDPPGPSKGSAAPSA 84

  Fly   362 DANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEA 426
                                |: ||.||:||.|||..||..|.::.||.::.||:|||.|.|.|:
Mouse    85 --------------------PQ-RRKRTSFSSEQLQLLELVFRQTMYPDIHLRERLAALTLLPES 128

  Fly   427 RVQVWFSNRRAKWRRH---------QRVNLIKQRDSPSTSSSPTPLVNPVVSPVSPIPVPVPVAV 482
            |:||||.|||||.||.         .|..:.....:|.|.:.......|:.:.|:.:|.|
Mouse   129 RIQVWFQNRRAKSRRQSGKSFQPLSSRRGVFLHCPAPGTEARCLKPQLPLEADVNHVPDP----- 188

  Fly   483 PESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSS 523
                      ..:...:|.:.|.|..:....:.:.|||:.|
Mouse   189 ----------SMTGGGVCTSGSQSFETYSSLSEDIGSKLDS 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	30/51 (59%)
Mixl1	NP_038757.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..93		25/123 (20%)
Mixl1	NP_038757.1	Homeobox	89..142	CDD:278475	30/52 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810