DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Vax1

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_033527.1	Gene:	Vax1 / 22326	MGIID:	1277163	Length:	338	Species:	Mus musculus

Alignment Length:	316	Identity:	81/316 - (25%)
Similarity:	118/316 - (37%)	Gaps:	83/316 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 SGSGCGDSSAGSGRLSLPALSPDSGSRDSRSPDADANRMI---DIEGEDSE-----SQDSDQPKF 384
            ||||..:..              :.|:.:.|.|.|..|.|   |.:|...|     ..|.|:||
Mouse    52 SGSGASEDC--------------NKSKSNSSADPDYCRRILVRDAKGSIREIILPKGLDLDRPK- 101

  Fly   385 RRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIK 449
             |.||:|:.|||..||.||.:..|.....|.:||.:..|||.:|:|||.|||.|.::.|
Mouse   102 -RTRTSFTAEQLYRLEMEFQRCQYVVGRERTELARQLNLSETQVKVWFQNRRTKQKKDQ------ 159

  Fly   450 QRDSPSTSSSPTPLVNPVVSPVSPI----------PVPVPVAVPESGQQKQPYPYSTSNMCNTSS 504
            .:||...|     :|:...:..|.:          |..:|..:|
Mouse   160 GKDSELRS-----VVSETAATCSVLRLLEQGRLLSPPGLPALLP--------------------- 198

  Fly   505 SSSNSQPCNTINPGSKMSSKT-SSVSSNQHMEEPAAAVATASPTASAPLSMGGENS-AFRALPMT 567
                  ||.|...||.:...: .::.:.......|||.|.|:.||..|.....::. |....|..
Mouse   199 ------PCATGALGSALRGPSLPALGAGAAAGSAAAAAAAAAATAPGPAGAASQHQPAVGGAPGP 257

  Fly   568 LP-----MPMTLPTASAAAFAL---SFARQYIAKYMGTPLNL-GHGSSPIQAQSGR 614
            .|     :....||||...|:|   |......::....||.: |..:..:|..|.|
Mouse   258 GPAGPGGLHAGAPTASHGLFSLPVPSLLGSVASRLSSAPLTMAGSLAGNLQELSAR 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	25/51 (49%)
Vax1	NP_033527.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..69		5/30 (17%)
		Homeobox	103..156	CDD:306543	25/52 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..269		4/29 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..338
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910