DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Rax

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_038861.2	Gene:	Rax / 19434	MGIID:	109632	Length:	342	Species:	Mus musculus

Alignment Length:	335	Identity:	98/335 - (29%)
Similarity:	130/335 - (38%)	Gaps:	103/335 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 PGGGPAGAGGAL--------QPGGSGSSYGS----------DGNMSSNPNSSNSNTTHSNGHNTN 327
            ||..||.|.|:.        .||||.|...|          ||.:.:.|...:|.::........
Mouse     4 PGCAPAMADGSFSLAGHLLRSPGGSTSRLHSIEAILGFTKEDGILDTFPAERSSRSSKERDPRLG 68

  Fly   328 SGSGCGDSSAGSGRLSLPALSPDSGSRDSRSPDADANRMI--DIEGE--------------DSES 376
            :...|..:.||....|.|| :|      ...|:.:|.|..  ..:||              ||:.
Mouse    69 AQPACPKAPAGGSESSPPA-AP------GFVPEYEATRPCYPKEQGEARPSPGLSVGPAAGDSKL 126

  Fly   377 QDSDQP--KFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKW 439
            .:.:.|  |.|||||||:..||.|||:.|:|||||.|.:||:||.:..|.|.||||||.||||||
Mouse   127 SEEEPPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAGKVNLPEVRVQVWFQNRRAKW 191

  Fly   440 RRHQR--VNLIKQRDSPSTSSSPTPLVNPVVSPVSPIPVPVPVAVPESGQQKQPYPYSTSNMCNT 502
            ||.::  |:.:|.:|||..|.|.:|
Mouse   192 RRQEKLEVSSMKLQDSPLLSFSRSP---------------------------------------- 216

  Fly   503 SSSSSNSQPCNTINPGSKMSSKTSSVSSNQHMEEPAAAVATASPTASAPLSMGGENSAFRALPMT 567
              .||...|..| .|||...              |..:.....|....||. ||..:|.::||..
Mouse   217 --PSSALAPLGT-GPGSGSG--------------PPGSALPLEPWLGPPLP-GGGATALQSLPGF 263

  Fly   568 LPMPMTLPTA 577
            .|....||.:
Mouse   264 GPPGQGLPAS 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	33/51 (65%)
Rax	NP_038861.2	Octapeptide motif	33..40		1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..140		22/102 (22%)
		Homeobox	140..192	CDD:278475	33/51 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..295		23/124 (19%)
		OAR	316..331	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	319..332
		Nuclear localization signal. /evidence=ECO:0000255	325..329
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910