DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and ceh-8

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_492246.2	Gene:	ceh-8 / 191617	WormBaseID:	WBGene00000433	Length:	276	Species:	Caenorhabditis elegans

Alignment Length:	289	Identity:	84/289 - (29%)
Similarity:	127/289 - (43%)	Gaps:	53/289 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 SNPNSSNSNTTH--SNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDSRSPDADANRMIDIEG 371
            |||..:||.|:.  .|....:|.:....|.:.|...|..:.|..|.||.:|...||
Worm     2 SNPTDNNSATSSITPNFSAFSSFTTYKPSDSFSSFESDSSPSKSSSSRKNRDKIAD--------- 57

  Fly   372 EDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRR 436
                      .|.|||||||:..||..||..|||:|||.|..||.|||:..|.|.||||||.|||
Worm    58 ----------KKQRRNRTTFTTFQLHALEAAFDKTHYPDVYARETLAAKVQLPEVRVQVWFQNRR 112

  Fly   437 AKWRRHQRVNLIKQ-----RDS-PSTS-----SSPTPLVNPVVSPVSPIPVPVPVAVPE----SG 486
            ||:||.::.:...:     :|: ||.|     .:.||   |::.|.:.:.......:.:    :.
Worm   113 AKFRRQEKQDCQGEEKHSLKDTMPSWSWMSENKTDTP---PMLPPANTLSSTHNNGISDEFFKTS 174

  Fly   487 QQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSSKTSSVSSNQHMEEPAAAVATASPTAS-- 549
            :.|:.|.:..:.....:.::..|:..|..:...:.|.|.|.      .:|.....:|:||..|
Worm   175 EGKEVYGFPFAEYGTPADNTHVSKTGNVFHLNFEDSDKKSM------KKESPQTPSTSSPFISEY 233

  Fly   550 ----APLSMGGE--NSAFRALPMTLPMPM 572
                .|..:..:  ::||...||..|.|:
Worm   234 HPPFIPYYIPNQSFSNAFNQYPMPFPYPI 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	33/51 (65%)
ceh-8	NP_492246.2	Homeobox	64..116	CDD:278475	33/51 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910