DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Phox2b

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_032914.1	Gene:	Phox2b / 18935	MGIID:	1100882	Length:	314	Species:	Mus musculus

Alignment Length:	324	Identity:	87/324 - (26%)
Similarity:	131/324 - (40%)	Gaps:	78/324 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 SGSSY-----GSDGNMSSNPNSSNSNTTHSNGHNTN-------SGSGCGDSSAGSGRLSLPALSP 349
            :.|:|     |.|.:..::..:..|:.:.::|...|       :.|||            |:|:|
Mouse    10 NSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGC------------PSLTP 62

  Fly   350 DSGS----RDSRSPD--ADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHY 408
            .|.|    ||.:|..  |...::....|..:|.:     |.||.||||:..||.|||:.|.::||
Mouse    63 GSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKR-----KQRRIRTTFTSAQLKELERVFAETHY 122

  Fly   409 PCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLI-----------KQRDS-------PS 455
            |.:.|||:||.:..|:||||||||.|||||:|:.:|....           |:.||       .:
Mouse   123 PDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSRDDESKEA 187

  Fly   456 TSSSPTPLVNPVVSPVSPIPVPVPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSK 520
            .|:.|.....|     .|.|.|.|......|....|.|..............        .||..
Mouse   188 KSTDPDSTGGP-----GPNPNPTPSCGANGGGGGGPSPAGAPGAAGPGGPGG--------EPGKG 239

  Fly   521 MSSKTSSVSSNQHMEEPAAAVATASPTASAPLSMGGENSAFRALPMTLPMPMT-LPTASAAAFA 583
            .::..::.::       |||.|.|:..|....:.||....:    ...|.|:| :|.:....||
Mouse   240 GAAAAAAAAA-------AAAAAAAAAAAGGLAAAGGPGQGW----APGPGPITSIPDSLGGPFA 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	32/51 (63%)
Phox2b	NP_032914.1	Homeobox	102..155	CDD:395001	32/52 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..246		15/96 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..289		7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910