DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and pax-2

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_500513.1	Gene:	pax-2 / 187062	WormBaseID:	WBGene00003938	Length:	351	Species:	Caenorhabditis elegans

Alignment Length:	279	Identity:	91/279 - (32%)
Similarity:	130/279 - (46%)	Gaps:	68/279 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 PTAATTV-LAQPHSLSP----------STPILTQGAPPAA-ALGGIFCGGSAAAGPGAAAAAATN 126
            ||.:.|| |.:..::.|          ..|:|:.|:.... .|||:|..|...  |....|
Worm    56 PTVSGTVSLPKAETVEPDLWIKSFKGNEDPLLSDGSHTGVNQLGGVFVNGRPL--PDTIRA---- 114

  Fly   127 LNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLL------GTLRPPGLIGGSKPKVATPTV 185
                    :::|:|:.|.|..|:::.:....|.|||:|      |::| ||:|||||||||||.|
Worm   115 --------QIVEMSQHGTRPCDISRQLKVSHGCVSKILGRYYSTGSVR-PGVIGGSKPKVATPRV 170

  Fly   186 VSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINRILRNRAAERAAAEFARAASYGYA 250
            |..|..|||.|||:||||||::||.:.:|.....|||||||||:||::.      .|:.|:
Worm   171 VECIAGYKRANPTMFAWEIRQKLIEDQICGEENVPSVSSINRIVRNKSF------MAQLAT---- 225

  Fly   251 IHPTHPHPYTSFPTWPAHHPLWGAVPLATPPG--GGPAGAGGALQPGGSG--------SSYGSDG 305
              ||...|..:.|:            .||...  ..|.|....:|...|.        :|..:..
Worm   226 --PTSVTPSVARPS------------SATSQNQRSPPRGVQQHMQQSTSVQQLQQFQLTSAATVN 276

  Fly   306 NMSSNPNSSNSNTTHS-NG 323
            ::.|.|..:...|||| ||
Worm   277 SLISRPAFAIPGTTHSING 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	52/101 (51%)
toe	NP_524041.2	Homeobox	388..440	CDD:278475
pax-2	NP_500513.1	PAX	91..215	CDD:128645	59/138 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910