Protein Alignment toe and Pax8

DIOPT Version :9

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_035170.1
• Gene: Pax8 / 18510
• MGIID: 97492
• Length: 457
• Species: Mus musculus
• Alignment Length: 541
• Identity: 151/541 - (27%)
• Similarity: 213/541 - (39%)
• Gaps: 167/541 - (30%)

  Fly   104 LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLL---- 164
            |||.|..|..             |..:..| |:::|:..|:|..|:::.:....|.|||:|
Mouse    16 LGGAFVNGRP-------------LPEVVRQ-RIVDLAHQGVRPCDISRQLRVSHGCVSKILGRYY 66

  Fly   165 --GTLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINR 227
              |::| ||:|||||||||||.||.||..|||:|||:||||||:||:.||||.|.|.||||||||
Mouse    67 ETGSIR-PGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINR 130

  Fly   228 ILRNRAAE-----RAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAG 287
            |:|.:..:     ..:....::.|.|:.:.|:                  .||   |||
Mouse   131 IIRTKVQQPFNLPMDSCVATKSLSPGHTLIPS------------------SAV---TPP------ 168

  Fly   288 AGGALQPGGSGSSYGSDGNMS-SNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDS 351
              .:.|....||:|..:|.:. :.|.:.|...             ..||...|.|||:.:.|..|
Mouse   169 --ESPQSDSLGSTYSINGLLGIAQPGNDNKRK-------------MDDSDQDSCRLSIDSQSSSS 218

  Fly   352 GSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREK 416
            |.|.....|                             |||...|:.||..|::.|||     |.
Mouse   219 GPRKHLRTD-----------------------------TFSQHHLEALECPFERQHYP-----EA 249

  Fly   417 LAA----------------RTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTPLVN 465
            .|:                .:||.:.:..:..||                  :|...:..|....
Mouse   250 YASPSHTKGEQGLYPLPLLNSALDDGKATLTSSN------------------TPLGRNLSTHQTY 296

  Fly   466 PVVS-PVSPIPVPVPVAVPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSSKTSSVS 529
            |||: |.||..:            ||..| ..|:..:|.||.|:|...:....||...:..|...
Mouse   297 PVVADPHSPFAI------------KQETP-ELSSSSSTPSSLSSSAFLDLQQVGSGGPAGASVPP 348

  Fly   530 SNQHMEEPAAAVATASPTASAPLSMGGENSAFRALPMTLP-MPMTLPTASAAAFALSFARQYIA- 592
            .|..   |.||......|..|.|| |.|     .:..||| .|..:||:...::|.|.....:|
Mouse   349 FNAF---PHAASVYGQFTGQALLS-GRE-----MVGPTLPGYPPHIPTSGQGSYASSAIAGMVAG 404

  Fly   593 -KYMGTPLNLGHGSSPIQAQS 612
             :|.|.    .:..:|..:.|
Mouse   405 SEYSGN----AYSHTPYSSYS 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	58/101 (57%)
		Homeobox	388..440	CDD:278475	16/67 (24%)
Pax8	NP_035170.1	PAX	9..133	CDD:128645	65/131 (50%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	12..68		17/65 (26%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	87..135		34/47 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..224		23/106 (22%)
		Pax2_C	344..455	CDD:372091	24/91 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810