DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toe and Pax6

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_001231127.1	Gene:	Pax6 / 18508	MGIID:	97490	Length:	436	Species:	Mus musculus

Alignment Length:	522	Identity:	161/522 - (30%)
Similarity:	226/522 - (43%)	Gaps:	178/522 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLS------------- 155
            |||:|..|.....              :::.:::||:..|.|..|:::.:.:
Mouse    11 LGGVFVNGRPLPD--------------STRQKIVELAHSGARPCDISRILQTHADAKVQVLDNEN 61

  Fly   156 -QQGAVSKLL------GTLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGV 213
             ..|.|||:|      |::||.. ||||||:||||.|||||.|||||.|:|||||||:||::|||
Mouse    62 VSNGCVSKILGRYYETGSIRPRA-IGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGV 125

  Fly   214 CTNATAPSVSSINRILRNRAAER----AAAEF-------ARAASYGYAIHPTHP--HPYTSFPTW 265
            |||...||||||||:|||.|:|:    |...:       .:..|:|     |.|  :|.||.|
Mouse   126 CTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWG-----TRPGWYPGTSVP-- 183

  Fly   266 PAHHPLWGAVPLATPPGGGPAGAGGALQPGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGS 330
                             |.|...|...|.||                          |.||||.|
Mouse   184 -----------------GQPTQDGCQQQEGG--------------------------GENTNSIS 205

  Fly   331 GCG-DSSAGSGRLSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPE 394
            ..| ||.....||.|                                    :.|.:||||:|:.|
Mouse   206 SNGEDSDEAQMRLQL------------------------------------KRKLQRNRTSFTQE 234

  Fly   395 QLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDS------ 453
            |::.|||||:::|||.|..||:|||:..|.|||:|||||||||||||.:::...:::.|
Mouse   235 QIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHI 299

  Fly   454 PSTSSSPTPLVNPVVSPVSPI------------------------PVPVPVAVPESGQQKQPYPY 494
            |.:||..|.:..|:..|.:|:                        |:| ...:..:...:.|.|.
Mouse   300 PISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMP-SFTMANNLPMQPPVPS 363

  Fly   495 STSN-MCNTSSSSS-NSQPCNTINP---GSKMSSKTSSVSSNQHMEEPAAAVATASPTASAPLSM 554
            .||: .|...:|.| |.:..:|..|   .:.|:|:....|.       ..:....||..|.|:.:
Mouse   364 QTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSG-------TTSTGLISPGVSVPVQV 421

  Fly   555 GG 556
            .|
Mouse   422 PG 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	57/115 (50%)
toe	NP_524041.2	Homeobox	388..440	CDD:278475	33/51 (65%)
Pax6	NP_001231127.1	PAX	4..142	CDD:128645	62/145 (43%)
Pax6	NP_001231127.1	Homeobox	228..281	CDD:395001	34/52 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810