DRSC/TRiP Functional Genomics Resources

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Protein Alignment toe and Pax4

DIOPT Version :9

Sequence 1:NP_524041.2 Gene:toe / 39418 FlyBaseID:FBgn0036285 Length:640 Species:Drosophila melanogaster
Sequence 2:NP_035168.1 Gene:Pax4 / 18506 MGIID:97488 Length:349 Species:Mus musculus


Alignment Length:447 Identity:127/447 - (28%)
Similarity:177/447 - (39%) Gaps:162/447 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLLGT-- 166
            |||:|..|...              .|.::.::::|:..|:|..|:::.:....|.|||:||.  
Mouse    12 LGGLFVNGRPL--------------PLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYY 62

  Fly   167 ---LRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINRI 228
               :..|..||||||::|||.||::|.|.|.|.|.:|||||:.:|.|||:||...|||||||||:
Mouse    63 RTGVLEPKCIGGSKPRLATPAVVARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPSVSSINRV 127

  Fly   229 LRNRAAERAAAEFARAASYGYAIHPTH-PHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGAL 292
            |             ||.....::|.|. ..|....|..|:.|...||                  
Mouse   128 L-------------RALQEDQSLHWTQLRSPAVLAPVLPSPHSNCGA------------------ 161

  Fly   293 QPGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDSR 357
                              |...:..|:|                                     
Mouse   162 ------------------PRGPHPGTSH------------------------------------- 171

  Fly   358 SPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTA 422
                                        ||||.|||.|.:.|||||.:..||....|.||||.|:
Mouse   172 ----------------------------RNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATS 208

  Fly   423 LSEARVQVWFSNRRAKWRRHQRV-----------NLIKQRDSP---STSSSPTPLVN---PVVSP 470
            |.|..|:||||||||||||.:::           :|...::||   |...||..:.:   ||:.|
Mouse   209 LPEDTVRVWFSNRRAKWRRQEKLKWEAQLPGASQDLTVPKNSPGIISAQQSPGSVPSAALPVLEP 273

  Fly   471 VSPI-------PVPVPVAVPESGQ-QKQPYPYSTSNMCNTSSSS--SNSQPCNTINP 517
            :||.       ..|...:...|.| ..||| :...::...:|||  ..:.||.|.:|
Mouse   274 LSPSFCQLCCGTAPGRCSSDTSSQAYLQPY-WDCQSLLPVASSSYVEFAWPCLTTHP 329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
toeNP_524041.2 HTH 134..230 CDD:304362 47/100 (47%)
Homeobox 388..440 CDD:278475 31/51 (61%)
Pax4NP_035168.1 PAX 5..129 CDD:128645 54/143 (38%)
PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381 8..64 16/65 (25%)
RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381 83..131 29/60 (48%)
Homeobox 174..226 CDD:278475 31/51 (61%)
Transcription repression 278..349 13/53 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0849
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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