Protein Alignment toe and Pax2

DIOPT Version :9

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_001355672.1
• Gene: Pax2 / 18504
• MGIID: 97486
• Length: 432
• Species: Mus musculus
• Alignment Length: 519
• Identity: 143/519 - (27%)
• Similarity: 191/519 - (36%)
• Gaps: 181/519 - (34%)

  Fly   104 LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDLAQHMLSQQGAVSKLLGTLR 168
            |||:|..|...  |...            :.|::||:..|:|..|:::.:....|.|||:||...
Mouse    23 LGGVFVNGRPL--PDVV------------RQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYY 73

  Fly   169 -----PPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERLITEGVCTNATAPSVSSINRI 228
                 .||:|||||||||||.||.||.:|||:|||:||||||:||:.||:|.|.|.|||||||||
Mouse    74 ETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRI 138

  Fly   229 LRNRAAERAAAEFARAASYGYAIHPTHPHPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAGGALQ 293
            :|.:..:              ..||| |....:..|.|.|        ...|....|..:..:..
Mouse   139 IRTKVQQ--------------PFHPT-PDGAGTGVTAPGH--------TIVPSTASPPVSSASND 180

  Fly   294 PGGSGSSYGSDGNMSSNPNSSN-------SNTTHSNGHNTNSGSG------CGDSSAGSGRLSLP 345
            |.||.|..|..|...||.....       ::..|..|     |.|      ..|.|.|    |:|
Mouse   181 PVGSYSINGILGIPRSNGEKRKREEVEVYTDPAHIRG-----GGGLHLVWTLRDVSEG----SVP 236

  Fly   346 ALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPC 410
                                    .|:.....||.:...|.:  ||:.:||:.|::.|::..||.
Mouse   237 ------------------------NGDSQSGVDSLRKHLRAD--TFTQQQLEALDRVFERPSYPD 275

  Fly   411 V------------NTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTPL 463
            |            |.....|....|.|.:                          .|.|:|..|.
Mouse   276 VFQASEHIKSEQGNEYSLPALTPGLDEVK--------------------------SSLSASANPE 314

  Fly   464 VNPVVSPVSPIPVPV------------PVAVPESGQQKQPYPYST-SNMCNTSSSSSNSQPCNTI 515
            :...||.....||..            |..||.:||..  ||.|| :.|.
Mouse   315 LGSNVSGTQTYPVVTGRDMTSTTLPGYPPHVPPTGQGS--YPTSTLAGMV--------------- 362

  Fly   516 NPGSKMSSKTSS----VSSNQ--HMEEPAAAVATASPTASAPLSMGGENSAFRALPMTLPMPMT 573
             |||:.|....|    .:.|:  ....||..:    |...||           .||: ||:|||
Mouse   363 -PGSEFSGNPYSHPQYTAYNEAWRFSNPALLM----PPPGAP-----------PLPL-LPLPMT 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	57/100 (57%)
		Homeobox	388..440	CDD:278475	13/63 (21%)
Pax2	NP_001355672.1	PAX	16..140	CDD:128645	63/130 (48%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75		18/65 (28%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		33/47 (70%)
		homeodomain	255..>278	CDD:381795	9/22 (41%)
		Pax2_C	305..>390	CDD:372091	24/102 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810