DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Nobox

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_570939.1	Gene:	Nobox / 18291	MGIID:	108011	Length:	527	Species:	Mus musculus

Alignment Length:	339	Identity:	80/339 - (23%)
Similarity:	136/339 - (40%)	Gaps:	67/339 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 NMSSNPNSSNSNTTHSNG----HNTNSGSGCGDSSAGSGRLSLPALSPDSGSRDSRSP------- 359
            ::...|.|..|......|    |...:.:.||..|...|      .||.....:|..|
Mouse    52 SLGKRPLSKTSEELMDAGTCRVHKAPTAAACGPQSEEEG------CSPPERKAESLKPSISAVPG 110

  Fly   360 DADANRMIDIEGEDSESQDSDQPKFR-RNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTAL 423
            .|.|..:...||:..:.......:|| :.||.:..:||:|||:.|.:.|||..:.|.:::....:
Mouse   111 QATAGSLNSHEGDLKKESLEVTCQFRKKTRTLYRSDQLEELERIFQEDHYPDSDKRHEISQMVGV 175

  Fly   424 SEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSS-------SPTPLVNPVVSPVSPIPVPVPVA 481
            :..|:.|||.|||||||:.:::|..:.::.|:..|       |...|::|:.:.:.|.|||
Mouse   176 TPQRIMVWFQNRRAKWRKVEKLNEKETKNGPAAPSADSSQHRSAPELLDPMPTDLEPGPVP---- 236

  Fly   482 VPESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINPGSKMSSKTSSVSSNQHMEEPAAAVATASP 546
             ||:.....|.|    .|..||.        .|:.|          ..:|:..|..|......||
Mouse   237 -PENILDVFPEP----PMLLTSE--------QTLTP----------FQNNEGAERVAVTPPLLSP 278

  Fly   547 ----TASAPLSMGGENSAFRALPMTLPMPMTLPTASAAAFALSFARQYIAKYMGTPLNLGHGSSP 607
                .|:.||.:|...:     |..||....:|.:.    ::...:.|::  .||.:......|.
Mouse   279 PPIRRANLPLPLGPVQT-----PQVLPPMRDVPGSD----SIYKDKAYVS--WGTSIASPPTYSN 332

  Fly   608 IQAQSGRDHQSEER 621
            ::....:|:|:..:
Mouse   333 LEDLGSQDYQASSQ 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	21/51 (41%)
Nobox	NP_570939.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..126		17/79 (22%)
		COG5576	94..213	CDD:227863	34/118 (29%)
		Homeobox	139..192	CDD:278475	21/52 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..245		12/55 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..306		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..527
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910