Protein Alignment toe and Nobox

DIOPT Version :10

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_570939.1
• Gene: Nobox / 18291
• MGIID: 108011
• Length: 527
• Species: Mus musculus
• Alignment Length: 828
• Identity: 142/828 - (17%)
• Similarity: 227/828 - (27%)
• Gaps: 368/828 - (44%)

  Fly    82 YRTQKSLMAEVK-GKNFVDHLNNNEPTPGSGIKR--------------------GFLFGNSICGE 125
            :...|||.:..| .|:.:.|..:....|.:||..                    |.|...|:.|.
Mouse   315 HHADKSLDSFCKWQKSILSHQGDGNSIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGM 379

  Fly   126 GSTSQDCNVGKDNKVLEVRPVKVRRTMIDLQLPADEYLHTEGDN-----TTC--PPYEQSKEVGE 183
            ....:.|::.:|..:.....:            |.|..|..|.|     .:|  ..:|.:|.:..
Mouse   380 CEPERSCSINEDIGLGSAFTI------------AHEIGHNFGMNHDGIGNSCGTKGHETAKLMAA 432

  Fly   184 NIFFESHRNDSSGSSLLMKNSNGFTDL-------NEPV-------------------QCQDSVPV 222
            :|  .::.|..|.|:........|.|.       |||:                   ||:.....
Mouse   433 HI--TANTNPFSWSACSKDYITSFLDSGRGTCLDNEPLKRDFLYPTVAPGQVYDADEQCRFQYGA 495

  Fly   223 SSSS-------RDLYSLYGAN------ISHVQGQWVEKNTSQNGWMVLEAGNGKSTPRDKLCLPS 274
            ||..       |:|:.|..:|      |...:|...:.||.:.||                |
Mouse   496 SSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTNTIEKGW----------------C--- 541

  Fly   275 HSVQVLSNSAFQPLGYPSTDHSKLSGERASFKCEVRQRNPEVSYDSYVESSVASNVPSLNHGYRP 339
                                   ..||..:|                              |..|
Mouse   542 -----------------------YQGECVAF------------------------------GTWP 553

  Fly   340 ESV----RPWSHW----------ISSWENRSSSSVQKPLPLQANPFLTFNTQVRADSSAEMRSRD 390
            :||    .||:.|          :||    |......|.|.....:.       .......||.:
Mouse   554 QSVDGSWGPWTVWGECSRTCGGGVSS----SMRHCDSPAPSGGGKYC-------LGERKRYRSCN 607

  Fly   391 SNGLNQGFSSFSEESAFNFPSVNFNHLNNGPKGAVTNGSLCESVMHQSLKNLQGPKKQECSSGLP 455
            ::...:|...|.|:...:|.|:.|       :|...|
Mouse   608 TDACPEGSRDFREKQCADFDSLPF-------RGKYYN---------------------------- 637

  Fly   456 WIKPKPLNKNGKTNGGLD---LNASA-NHQFMDERD---------MGDSSNYVHPQNGLRSVTCS 507
            |   ||.     |.||:.   ||..| .:.|..||.         .|||.:           .|.
Mouse   638 W---KPY-----TGGGVKPCALNCLAEGYNFYTERSPAVIDGTRCQGDSLD-----------ICI 683

  Fly   508 NDANLRHVEMAN------SQSRRKILGFPISQKLSICEEHPSLITSSVCISNEPK----KVNNLV 562
            | ...:||...|      .:.|.::.|    ...|.||....|...|:     |:    :|..:.
Mouse   684 N-GECKHVGCDNILGSDAKEDRCRVCG----GDGSTCELTEGLFNDSL-----PRGGYMEVVQIP 738

  Fly   563 KINLDINLPCEASVSEGVVVDKEEG-----NKAATHRQHID-----------LNFCASEDEDSGF 611
            |.::.|.:. |.:||:..:..|.||     |.|.|    ||           .::....||...
Mouse   739 KGSVHIEIR-EVAVSKNYIALKSEGDDYYINGAWT----IDWPRKFDIAGTAFHYKRPTDEPES- 797

  Fly   612 CSNPRVETKATTLINVEAPLTLESEEEGGKF----PEKRDEAGDSVDELIEAAAEAIVTISLSYH 672
                 :|....|:.|:...:.|:.:..|.::    |.:|..:||:             .:..|:|
Mouse   798 -----LEALGATMENLVVMVLLQEQNLGIQYKFNVPIQRTGSGDN-------------EVGFSWH 844

  Fly   673 ---------------------CRNTDEAASSSTDAVDKE---------------PLSWFVNTIAS 701
                                 |:..|:.:.......|::               |..||:...:.
Mouse   845 HLPWSECSATCAGGSQKQEVVCKRLDDNSVVQNSYCDQDSKPPGNQRRCNTEPCPPEWFIGDWSE 909

  Fly   702 CGNDLESKI---------------------DACLEARDCEGCREECSS 728
            ||...:..|                     ..||..|..|  :|.|::
Mouse   910 CGKTCDGGIRTRTVLCIRKINPAEEETLEDSHCLTHRPIE--QESCNN 955

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH_ARSR	134..230	CDD:481197	23/135 (17%)
		Homeodomain	385..441	CDD:459649	10/55 (18%)
Nobox	NP_570939.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..126
		COG5576	94..213	CDD:227863
		Homeodomain	137..193	CDD:459649
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..245
		PHA03247	<206..454	CDD:223021	27/152 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	271..306
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..527		9/38 (24%)