DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Hoxb8

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_034591.1	Gene:	Hoxb8 / 15416	MGIID:	96189	Length:	243	Species:	Mus musculus

Alignment Length:	219	Identity:	51/219 - (23%)
Similarity:	76/219 - (34%)	Gaps:	61/219 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 YTSFPTWPAHHPLWGAVPLATPPGG------GPAGAGGALQPGGSGSSYGSDGNMSSNPNSSNSN 317
            ::.:.|..:..|.:.....|...||      ||:..|....|......|....::|:.|...|..
Mouse    10 FSKYKTGESLRPNYYDCGFAQDLGGRPTVVYGPSSGGSFQHPSQIQEFYHGPSSLSTAPYQQNPC 74

  Fly   318 TTHSNGHNTN-----------------------------SGSGCGDSSAGSGRLSLPA-LSPDSG 352
            ....:|...|                             :.||.|:.:.||.:...|. |.|
Mouse    75 AVACHGDPGNFYGYDPLQRQSLFGAQDPDLVQYADCKLAAASGLGEEAEGSEQSPSPTQLFP--- 136

  Fly   353 SRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKL 417
               ...|.|.|.|                   ||.|.|:|..|..||||||..:.|.....|.::
Mouse   137 ---WMRPQAAAGR-------------------RRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEV 179

  Fly   418 AARTALSEARVQVWFSNRRAKWRR 441
            :....|:|.:|::||.|||.||::
Mouse   180 SHALGLTERQVKIWFQNRRMKWKK 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	21/51 (41%)
Hoxb8	NP_034591.1	Antp-type hexapeptide	134..139		2/10 (20%)
		Homeobox	150..203	CDD:395001	22/52 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..243		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910