DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toe and Nkx6-2

DIOPT Version :9

Sequence 1:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster
Sequence 2:	NP_899071.2	Gene:	Nkx6-2 / 14912	MGIID:	1352738	Length:	277	Species:	Mus musculus

Alignment Length:	250	Identity:	69/250 - (27%)
Similarity:	101/250 - (40%)	Gaps:	60/250 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 NRAAERAAAEFARAASYGYAIHPTHPHPY-----TSFPTWPAHHPLWGAVPLATPPG-----GGP 285
            ||......:....||.:..|...|...||     ..|.| ||...|...:||.||.|     |.|
Mouse     4 NRPGAFVLSSAPLAALHNMAEMKTSLFPYALQGPAGFKT-PALGSLGAQLPLGTPHGISDILGRP 67

  Fly   286 AGAGGALQPGGSGSSYGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDSSA------------- 337
            .||.|.             |.:.|.|        ..||..:::|...|.::|
Mouse    68 VGAAGG-------------GLLGSLP--------RLNGLASSAGVYFGPAAAVARGYPKPLAELP 111

  Fly   338 GSGRLSLPALSPDSGSRDSR-SPDADANRMIDIEGEDSESQDSDQPKFRRNRTTFSPEQLDELEK 401
            |...:..|.:...|..||.| :..|.|..::|.:|           |.:.:|.|||.:|:..|||
Mouse   112 GRPPIFWPGVVQGSPWRDPRLAGSAQAGGVLDKDG-----------KKKHSRPTFSGQQIFALEK 165

  Fly   402 EFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLI---KQRDS 453
            .|:::.|.....|.:||....::|::|:|||.|||.|||:.....:.   |::||
Mouse   166 TFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAAEMASAKKKQDS 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362
toe	NP_524041.2	Homeobox	388..440	CDD:278475	22/51 (43%)
Nkx6-2	NP_899071.2	Homeobox	151..205	CDD:395001	23/53 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910