Protein Alignment toe and NKX2-6

DIOPT Version :9

• Sequence 1: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Sequence 2: NP_001129743.2
• Gene: NKX2-6 / 137814
• HGNCID: 32940
• Length: 301
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 86/369 - (23%)
• Similarity: 120/369 - (32%)
• Gaps: 117/369 - (31%)

  Fly   217 ATAPSVSSINRILRNRAAERAAAEFARAASYGYAIHPTHPHP----------YTSFPTWPAHHPL 271
            :|..||..|.|:.|.|:...|:                 |||          |......|....:
Human     8 STPFSVKDILRLERERSCPAAS-----------------PHPRVRKSPENFQYLRMDAEPRGSEV 55

  Fly   272 WGAVPLATPPGGGPAGAGGALQPGGSGSS-YGSDGNMSSNPNSSNSNTTHSNGHNTNSGSGCGDS 335
            ..|     ..|||.....|:..|||...: ...|......|..
Human    56 HNA-----GGGGGDRKLDGSEPPGGPCEAVLEMDAERMGEPQP---------------------- 93

  Fly   336 SAGSGRLSLPALSPDSGSRDSRSPDADANRMIDIEGEDSESQDSDQPKFRRN---RTTFSPEQLD 397
                   .|.|.||..|.  :|.|:    |.:...|:......|:|||.|:.   |..||..|:.
Human    94 -------GLNAASPLGGG--TRVPE----RGVGNSGDSVRGGRSEQPKARQRRKPRVLFSQAQVL 145

  Fly   398 ELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFSNRRAKWRRHQRVNLIKQRDSPSTSSSPTP 462
            .||:.|.:..|.....||.||:...|:..:|::||.|||.|.:|        ||...|...:..|
Human   146 ALERRFKQQRYLSAPEREHLASALQLTSTQVKIWFQNRRYKCKR--------QRQDKSLELAGHP 202

  Fly   463 LVNPVVSPVSPIPVPVPVAV--------PESGQQKQPYPYSTSNMCNTSSSSSNSQPCNTINP-- 517
            |        :|..|.|||.|        |..|....|.|||.:                 ::|
Human   203 L--------TPRRVAVPVLVRDGKPCLGPGPGAPAFPSPYSAA-----------------VSPYS 242

  Fly   518 --GSKMSSKTSSVSSNQHMEEPAAAVATASPTASAPLSMGGENS 559
              |....:...:.....:...|:.. |..:|.|||....||:|:
Human   243 CYGGYSGAPYGAGYGTCYAGAPSGP-APHTPLASAGFGHGGQNA 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toe	NP_524041.2	HTH	134..230	CDD:304362	5/12 (42%)
		Homeobox	388..440	CDD:278475	20/51 (39%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..135		31/169 (18%)
		HOX	132..188	CDD:197696	20/55 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910